Now showing items 21-40 of 1022

    • Soluble klotho and heparin modulate the pathologic cardiac actions of FGF23 in chronic kidney disease 

      Yanucil, C.; Kentrup, D.; Campos, I.; Czaya, B.; Heitman, K.; Westbrook, D.; Osis, G.; Grabner, A.; Wende, A.R.; Vallejo, J.; Wacker, M.; Alberto Navarro-Garcia, J.; Ruiz-Hurtado, G.; Zhang, F.; Song, Y.; Linhardt, Robert J.; White, K.; Kapiloff, M.; Faul, C. (Elsevier, 2022)
      Fibroblast growth factor (FGF) 23 is a phosphate-regulating hormone that is elevated in patients with chronic kidney disease and associated with cardiovascular mortality. Experimental studies showed that elevated FGF23 ...
    • Intrinsically disordered N-terminal domain (NTD) of p53 interacts with mitochondrial PTP regulator Cyclophilin D 

      Zhao, J.; Liu, X.; Blayney, A.; Zhang, Y.; Gandy, L.; Mirsky, P.O.; Smith, N.; Zhang, F.; Linhardt, Robert J.; Chen, J.; Baines, C.; Loh, S.N.; Wang, C. (Elsevier, 2022)
      Mitochondrial permeability transition pore (mPTP) plays crucial roles in cell death in a variety of diseases, including ischemia/reperfusion injury in heart attack and stroke, neurodegenerative conditions, and cancer. To ...
    • Complete biosynthesis of a sulfated chondroitin in Escherichia coli 

      Badri, Abinaya; Williams, Asher; Awofiranye, Adeola; Datta, Payel; Xia, Ke; He, Wenqin; Fraser, Keith; Dordick, Jonathan S.; Linhardt, Robert J.; Koffas, Mattheos A.G. (Nature, 2021-12-01)
      Sulfated glycosaminoglycans (GAGs) are a class of important biologics that are currently manufactured by extraction from animal tissues. Although such methods are unsustainable and prone to contamination, animal-free ...
    • Platelet factor 4 polyanion immune complexes: Heparin induced thrombocytopenia and vaccine-induced immune thrombotic thrombocytopenia 

      Datta, Payel; Zhang, Fuming; Dordick, Jonathan S.; Linhardt, Robert J. (Springer, 2021-12-01)
      Background: This is a review article on heparin-induced thrombocytopenia, an adverse effect of heparin therapy, and vaccine-induced immune thrombotic thrombocytopenia, occurring in some patients administered certain ...
    • Anti-SARS-CoV-2 activity of rhamnan sulfate from Monostroma nitidum 

      Song, Yuefan; He, Peng; Rodrigues, Andre L.; Datta, Payel; Tandon, Ritesh; Bates, John T.; Bierdeman, Michael A.; Chen, Chen; Dordick, Jonathan; Zhang, Fuming; Linhardt, Robert J. (Multidisciplinary Digital Publishing Institute (MDPI), 2021-12-01)
      The COVID-19 pandemic is a major human health concern. The pathogen responsible for COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), invades its host through the interaction of its spike (S) protein ...
    • Structural study of AAVrh.10 Receptor and Antibody Interactions 

      Mietzsch, Mario; Yu, Jennifer C.; Hsi, Jane; Chipman, Paul; Broecker, Felix; Fuming, Zhang; Linhardt, Robert J.; Seeberger, Peter H.; Heilbronn, Regine; McKenna, Robert; Agbandje-McKenna, Mavis (2021-12-01)
      Recombinant adeno-associated virus (rAAV) vectors are one of the leading tools for the delivery of therapeutic genes in human gene therapy applications. For a successful transfer of their payload, the AAV vectors have to ...
    • Comparative study on the mechanisms of anti-lung cancer activities of three sulfated galactofucans 

      Zhang, Wenjing; Wu, Wanli; Bao, Yizhong; Yan, Xiaojun; Zhang, Fuming; Linhardt, Robert J.; Jin, Weihua; Mao, Genxiang (2021-11-07)
      Sulfated galactofucans, as the active compositions of fucoidan, were reported to exhibit antitumor activity. In the current study, a sulfated galactofucan (SGF) from Sargassum thunbergii and its three derivatives (SGF-H, ...
    • Anti-inflammation effects of highly purified low-Mw RG-I pectins on LPS-activated macrophages 

      Wu, Dongmei; Zheng, Xiaoliang; Hu, Weiwei; Zhu, Kai; Yu, Chengxiao; He, Qiaojun; Linhardt, Robert J.; Ye, Xingqian; Chen, Shiguo (2021-11-01)
      Pectic oligosaccharides are viewed as excellent immunomodulator, but the specific molecular weight (Mw) range required for anti-inflammatory effects remains unclear. In this study, citrus pectins was depolymerized by the ...
    • Challenges of pectic polysaccharides as a prebiotic from the perspective of fermentation characteristics and anti-colitis activity 

      Chengxiao, Yu; Dongmei, Wu; Kai, Zhu; Hou, Lijuan; Xiao, Hang; Ding, Tian; Liu, Donghong; Ye, Xingqian; Linhardt, Robert J.; Chen, Shiguo (2021-10-15)
      Several studies are described that contribute to the systematic exploration of new aspects of digestion, fermentation, and biological activities of pectic polysaccharides (PPS) leading to a better understanding of prebiotics. ...
    • Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function 

      Patel, Vaishali N.; Pineda, Dallas L.; Berenstein, Elsa; Hauser, Belinda R.; Choi, Sophie; Prochazkova, Michaela; Zheng, Changyu; Goldsmith, Corinne M.; van Kuppevelt, Toin H.; Kulkarni, Ashok; Song, Yuefan; Linhardt, Robert J.; Chibly, Alejandro M.; Hoffman, Matthew P. (Elsevier, 2021-09-01)
      Heparan sulfate 3-O-sulfotransferases generate highly sulfated but rare 3-O-sulfated heparan sulfate (HS) epitopes on cell surfaces and in the extracellular matrix. Previous ex vivo experiments suggested functional redundancy ...
    • Electrical Stimulation of Neural-Differentiating iPSCs on Coaxial Nanofibers 

      Garrudo, F.F.F.; Nogueira, D.E.S.; Rodrigues, C.A.V.; Ferreir, F.A.; Paradiso, P.; Colaço, R.; Marques, A.C.; Cabral, J.M.S.; Morgado, J.; Linhardt, Robert J.; Ferreira, F.C. (2021-08-07)
      Neural tissue engineering strategies are paramount to create fully mature neurons, necessary for new therapeutic strategies for neurological diseases or the creation of reliable in vitro models. Scaffolds can provide ...
    • PEDOT:PSS-coated polybenzimidazole electroconductive nanofibers for biomedical applications 

      Sordini, L.; Silva, J.C.; Garrudo, F.F.F.; Rodrigues, C.A.V.; Marques, A.C.; Linhardt, Robert J.; Cabral, J.M.S.; Morgado, J.; Castelo Ferreira, F. (Multidisciplinary Digital Publishing Institute (MDPI), 2021-08-02)
      Bioelectricity drives several processes in the human body. The development of new materials that can deliver electrical stimuli is gaining increasing attention in the field of tissue engineering. In this work, novel, highly ...
    • Red algal sulfated galactan binds and protects neural cells from HIV-1 gp120 and Tat 

      Pomin, Vitor H.; Mahdi, Fakhri; Jin, Weihua; Zhang, Fuming; Linhardt, Robert J.; Paris, Jason J. (2021-08-01)
      The potential neuroprotective capacity of four different sulfated glycans: Botryocladia occidentalis-derived sulfated galactan (BoSG) (MW > 100 kDa), Lytechinus variegatus-derived sulfated fucan (LvSF) (MW~90 kDa), ...
    • The degree of polymerization and sulfation patterns in heparan sulfate are critical determinants of cytomegalovirus entry into host cells 

      Mitra, Dipanwita; Hasan, Mohammad H.; Bates, John T.; Bierdeman, Michael A.; Ederer, Dallas R.; Parmar, Rinkuben C.; Fassero, Lauren A.; Liang, Quntao; Qiu, Hong; Tiwari, Vaibhav; Zhang, Fuming; Linhardt, Robert J.; Sharp, Joshua S.; Wang, Lianchun; Tandon, Ritesh (Public Library of Science (PLoS), 2021-08-01)
      Several enveloped viruses, including herpesviruses attach to host cells by initially interacting with cell surface heparan sulfate (HS) proteoglycans followed by specific coreceptor engagement which culminates in virus-host ...
    • Sustained release of Ganoderma lucidum antitumor drugs using a sandwich structured material prepared by electrospinning 

      Lu, Jiahui; Li, Yanying; Zhang, Anqiang; Liu, Weiming; Wang, Xingli; Zhang, Fuming; Linhardt, Robert J.; Lin, Zhibin; Sun, Peilong (2021-08-01)
      In cancer therapy, there still remains great challenges such as controlling cancer metastasis and the side effects from chemotherapy. Many anti-cancer drugs have cytotoxicity to normal cell with a high concentration, on ...
    • Prolonged release and shelf-life of anticoagulant sulfated polysaccharides encapsulated with ZIF-8 

      Zheng, Jie; Li, Bingzhi; Ji, Yuan; Chen, Yin; Lv, Xun; Zhang, Xing; Linhardt, Robert J. (2021-07-31)
      Natural active polysaccharides are attracting increased attention from pharmaceutical industries for their valuable biological activities. However, the application of polysaccharides has been restricted due to their ...
    • Heparan sulfate facilitates spike protein-mediated SARS-Cov-2 host cell invasion and contributes to increased infection of SARS-Cov-2 G614 mutant and in lung cancer 

      Yue, Jingwen; Jin, Weihua; Yang, Hua; Faulkner, John; Song, Xuehong; Qiu, Hong; Teng, Michael; Azadi, Parastoo; Zhang, Fuming; Linhardt, Robert J.; Wang, Lianchun (Multidisciplinary Digital Publishing Institute (MDPI), 2021-06-11)
      The severe acute respiratory syndrome (SARS)-like coronavirus disease (COVID-19) is caused by SARS-CoV-2 and has been a serious threat to global public health with limited treatment. Cellular heparan sulfate (HS) has been ...
    • Recent Progress and Advanced Technology in Carbohydrate-Based Drug Development 

      Pan, Lin; Cai, Chao; Liu, Chanjuan; Liu, Di; Li, Guoyun; Linhardt, Robert J.; Yu, Guangli (2021-06-01)
      Carbohydrates, one of the most abundant and widespread biomolecules in nature, play indispensable roles in diverse biological functions, and represent a treasure trove of untapped potential for pharmaceutical applications. ...
    • The sulfation code of tauopathies: heparan sulfate proteoglycans in the prion like spread of tau pathology 

      Mah, Dylan; Zhao, Jing; Liu, Xinyue; Zhang, Fuming; Liu, Jian; Wang, Lianchun; Linhardt, Robert; Wang, Chunyu (Frontiers Media SA, 2021-05-20)
      Tauopathies are a heterogenous family of progressive neurodegenerative diseases defined by the appearance of proteinaceous lesions within the brain composed of abnormally folded species of Microtubule Associated Protein ...
    • Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus 

      Yan, Lufeng; Song, Yuefan; Xia, Ke; He, Peng; Zhang, Fuming; Chen, Shiguo; Pouliot, Robert; Weiss, Daniel J.; Tandon, Ritesh; Bates, John T.; Ederer, Dallas R.; Mitra, Dipanwita; Sharma, Poonam; Davis, April; Linhardt, Robert J. (2021-05-15)
      Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has resulted in a pandemic and continues to spread at an unprecedented rate around the world. Although a vaccine has recently been approved, there are ...