Browsing Linhardt Research Labs Papers by Issue Date
Now showing items 61-80 of 1022
-
Heparin-mediated dimerization of follistatin
(2021-02-01)Heparin and heparan sulfate (HS) are highly sulfated polysaccharides covalently bound to cell surface proteins, which directly interact with many extracellular proteins, including the transforming growth factor-β (TGFβ) ... -
Detection of glycosaminoglycans by polyacrylamide gel electrophoresis and silver staining
(Jove, 2021-02-01)Sulfated glycosaminoglycans (GAGs) such as heparan sulfate (HS) and chondroitin sulfate (CS) are ubiquitous in living organisms and play a critical role in a variety of basic biological structures and processes. As polymers, ... -
Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin derivatives
(American Society for Microbiology, 2021-02-01)Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has caused a pandemic of historic proportions and continues to spread globally, with enormous consequences to human health. Currently there is no vaccine, ... -
Coupling liquid chromatography and tandem mass spectrometry to electrophoresis for in-depth analysis of glycosaminoglycan drugs: heparin and the multicomponent sulodexide
(2021-01-26)Glycosaminoglycans (GAGs) contribute to the treatment of many human diseases, especially in the field of thrombosis, because of their anticoagulant activity. GAGs interrupt the coagulation process by interacting with ... -
A rolling circle amplification based platform for ultrasensitive detection of heparin
(2021-01-21)Heparin has a variety of pharmacological uses, including applications for anti-tumor metastasis, anti-inflammatory and anti-viral activities and is widely used as a clinical anticoagulant. Due to its widespread applications ... -
Oral administration of fucosylated chondroitin sulfate oligomers in gastro-resistant microcapsules exhibits a safe antithrombotic activity
(2021-01-01)Fucosylated chondroitin sulfate (FCS) polysaccharide isolated from sea cucumber has potent anticoagulant activity. Based on its resistance to the enzymes present in vertebrates, it may serve as an anticoagulant and shows ... -
Polyaniline-Polycaprolactone Fibers for Neural Applications: Electroconductivity Enhanced by Pseudo-Doping
(2021-01-01)Replenishing neurons in patients with neurodegenerative diseases is one of the ultimate therapies for these progressive, debilitating and fatal diseases. Electrical stimulation can improve neuron stem cell differentiation ... -
Synthesis of selected unnatural sugar nucleotides for biotechnological applications
(Taylor and Francis, 2021-01-01)Sugar nucleotides are the principal building blocks for the synthesis of most complex carbohydrates and are crucial intermediates in carbohydrate metabolism. Uridine diphosphate (UDP) monosaccharides are among the most ... -
Oral fate and stabilization technologies of lactoferrin: a systematic review
(2021-01-01)Lactoferrin (Lf), a bioactive protein initially found in many biological secretions including milk, is regarded as the nutritional supplement or therapeutic ligand due to its multiple functions. Research on its mode of ... -
PBN11-8, a cytotoxic polypeptide purified from marine Bacillus, suppresses invasion of human hepatocellular carcinoma cells by targeting focal adhesion kinase pathways
(Multidisciplinary Digital Publishing Institute (MDPI), 2021-01-01)The development of antitumor drugs has attracted cancer researchers and the identification of novel antitumor lead compounds is certainly of great interest. The fermentation broth of Bacillus sp. N11-8, which was isolated ... -
Differential effect of homologous NicR2A/NicR2Bs and endogenous ectopic strong promoters on nicotine metabolism in Pseudomonas sp. JY-Q
(2021)Nicotine is a toxic environmental pollutant that widely exists in tobacco wastes. As a natural nicotine-degrading strain, Pseudomonas sp. strain JY-Q still has difficulties degrading high concentrations of nicotine. In ... -
Implications of Glycosaminoglycans on Viral Zoonotic Diseases
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)Zoonotic diseases are infectious diseases that pass from animals to humans. These include diseases caused by viruses, bacteria, fungi, and parasites and can be transmitted through close contact or through an intermediate ... -
Geometrical characteristics of eggs from three poultry species
(Elsevier, 2021)We studied the correlations between egg geometrical parameters (i.e., egg shape index, sphericity, geometric mean diameter, surface area, and volume) and eggshell qualities, or the organic matrix in eggshell. Eggs were ... -
Dietary pectic substances enhance gut health by its poly-component: A review
(2021)Pectic substances, one of the cell wall polysaccharides, exist widespread in vegetables and fruits. A surge of recent research has revealed that pectic substances can inhibit gut inflammation and relieve inflammatory bowel ... -
Bioengineered production of glycosaminoglycans and their analogues
(2021)Glycosaminoglycans (GAGs) are a class of linear polysaccharides, consisting of alternating disaccharide sequences of uronic acid and hexosamines (or galactose) with and without sulfation. They can interact with various ... -
Effects of glycosaminoglycan supplementation in the chondrogenic differentiation of bone marrow- and synovial- derived mesenchymal stem/stromal cells on 3D-extruded poly (ε-caprolactone) scaffolds
(2021)The lack of effective and long-term treatments for articular cartilage defects has increased the interest for innovative tissue engineering strategies. Such approaches, combining cells, biomaterial matrices and external ... -
Detection of Protamine Using a Promising Metal Organic Frameworks Based Fluorescent 1 Molecular Device BZA-BOD@ZIF-90
(2021)Herein, we designed a BODIPY-based probe ([email protected]) with good stability through the encapsulation of metal-organic frameworks (MOFs). [email protected] can selectively detect protamine based on an aggregation-induced ... -
Probing Aβ interactions with synthetic heparan sulfate oligosaccharides
(2021)Heparan sulfate (HS) can play important roles in the biology and pathology of amyloid β (Aβ), a hallmark of Alzheimer's disease. To better understand the structure-activity relationship of HS/Aβ interactions, synthetic HS ... -
High density fermentation of probiotic E. coli Nissle1917 towards heparosan production, characterization, and modification
(2021)Heparosan is a naturally occurring non-sulfated glycosaminoglycan. Heparosan serves as the substrate for chemoenzymatic synthesis of biopharmaceutically important heparan sulfate and heparin. Heparosan is biologically inert ... -
Ischemic stroke disrupts the endothelial glycocalyx through activation of proHPSE via acrolein exposure
(The American Society for Biochemistry and Molecular Biology (ASBMB) and Elsevier, 2020-12-25)Infiltration of peripheral immune cells after blood-brain barrier dysfunction causes severe inflammation after a stroke. Although the endothelial glycocalyx, a network of membrane-bound glycoproteins and proteoglycans that ...