Browsing Linhardt Research Labs Papers by Author "Agyekum, Isaac"

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Structural Analysis of Heparin-Derived 3-O-Sulfated Tetrasaccharides: Antithrombin Binding Site Variants

Chen, Yin; Lin, Lei; Agyekum, Isaac; Zhang, Xing; St. Ange, Kalib; Yu, Yanlei; Zhang, Fuming; Liu, Jian; Amster, I. Jonathan; Linhardt, Robert J. (Elsevier, 2017-04-01)

Heparin is a polysaccharide that is widely used as an anticoagulant drug. The mechanism for heparin's anticoagulant activity is primarily through its interaction with a serine protease inhibitor, antithrombin III (AT), ...
Structural elucidation of fucosylated chondroitin sulfates from sea cucumber using FTICR-MS/MS

Agyekum, Isaac; Pepi, Lauren; Yu, Yanlei; Li, Junhui; Yan, Lufeng; Linhardt, Robert J.; Chen, Shiguo; Amster, I. Jonathan (Sage, 2018-02-01)

Fucosylated chondroitin sulfates are complex polysaccharides extracted from sea cucumber. They have been extensively studied for their anticoagulant properties and have been implicated in other biological activities. While ...