Browsing Linhardt Research Labs Papers by Author "Baik, Jong Youn"

Now showing items 1-4 of 4

    • Bioengineered Chinese hamster ovary cells with Golgi-targeted 3-O-sulfotransferase-1 biosynthesize heparan sulfate with an antithrombin binding site 

      Datta, Payel; Li, Guoyun; Yang, Bo; Zhao, Xue; Baik, Jong Youn; Gemmill, Trent R.; Sharfstein, Susan T.; Linhardt, Robert J. (The American Society for Biochemistry and Molecular Biology (ASBMB) and Elsevier, 2013-12-27)
      HS3st1 (heparan sulfate 3-O-sulfotransferase isoform-1) is a critical enzyme involved in the biosynthesis of the antithrombin III (AT)-binding site in the biopharmaceutical drug heparin. Heparin is a highly sulfated ...

    • Bioengineering murine mastocytoma cells to produce anticoagulant heparin 

      Gasimli, Leyla; Glass, Charles A.; Datta, Payel; Yang, Bo; Li, Guoyun; Gemmill, Trent R.; Baik, Jong Youn; Sharfstein, Susan T.; Esko, Jeffrey D.; Linhardt, Robert J. (2014-03-01)
      Heparin (HP), an important anticoagulant polysaccharide, is produced in a complex biosynthetic pathway in connective tissue-type mast cells. Both the structure and size of HP are critical factors determining the anticoagulation ...

    • Metabolic engineering of Chinese hamster ovary cells: Towards a bioengineered heparin 

      Baik, Jong Youn; Gasimli, Leyla; Yang, Bo; Datta, Payel; Zhang, Fuming; Glass, Charles A.; Esko, Jeffrey D.; Linhardt, Robert J.; Sharfstein, Susan T. (Elsevier, 2012-03-01)
      Heparin is the most widely used pharmaceutical to control blood coagulation in modern medicine. A health crisis that took place in 2008 led to a demand for production of heparin from non-animal sources. Chinese hamster ...

    • Optimization of bioprocess conditions improves production of a CHO cell-derived, bioengineered heparin 

      Baik, Jong Youn; Dahodwala, Hussain; Oduah, Eziafa; Talman, Lee; Gemmill, Trent R.; Gasimli, Leyla; Datta, Payel; Yang, Bo; Li, Guoyun; Zhang, Fuming; Li, Lingyun; Linhardt, Robert J.; Campbell, Andrew M.; Gorfien, Stephen F.; Sharfstein, Susan T. (Wiley, 2015-07-01)
      Heparin is the most widely used anticoagulant drug in the world today. Heparin is currently produced from animal tissues, primarily porcine intestines. A recent contamination crisis motivated development of a non-animal-derived ...