Browsing Linhardt Research Labs Papers by Author "Cabral, Joaquim M.S."
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Functionalization of electrospun nanofibers and fiber alignment enhance neural stem cell proliferation and neuronal differentiation
Amores de Sousa, Miriam C.; Rodrigues, Carlos A.V.; Ferreira, Inês A. F.; Diogo, Maria Margarida; Linhardt, Robert J.; Cabral, Joaquim M.S.; Ferreira, Frederico Castelo (Frontiers Media SA, 2020-10-26)Neural stem cells (NSCs) have the potential to generate the cells of the nervous system and, when cultured on nanofiber scaffolds, constitute a promising approach for neural tissue engineering. In this work, the impact of ... -
Loss and rescue of osteocalcin and osteopontin modulate osteogenic and angiogenic features of mesenchymal stem/stromal cells
Carvalho, Marta S.; Silva, João C.; Hoff, Christopher M.; Cabral, Joaquim M.S.; Linhardt, Robert J.; da Silva, Cláudia L.; Vashishth, Deepak (2020-10-01)Noncollagenous proteins in the bone extracellular matrix, such as osteocalcin (OC) and osteopontin (OPN), inherent to evolution of bone as a skeletal tissue, are known to regulate bone formation and mineralization. However, ... -
Three Dimensional Cellular Microarray Platform for Human Neural Stem Cell Differentiation and Toxicology
Meli, Luciana; Barbosa, Hélder S.C.; Hickey, Anne Marie; Gasimli, Leyla; Nierode, Gregory; Diogo, Maria Margarida; Linhardt, Robert J.; Cabral, Joaquim M.S.; Dordick, Jonathan S. (Elsevier, 2014-01-01)We developed a three-dimensional (3D) cellular microarray platform for the high-throughput (HT) analysis of human neural stem cell (hNSC) growth and differentiation. The growth of an immortalized hNSC line, ReNcell VM, was ...