Now showing items 1-1 of 1

    • Synthetic oligosaccharides can replace animal-sourced low-molecular weight heparins 

      Xu, Yongmei; Chandarajoti, Kasemsiri; Zhang, Xing; Pagadala, Vijayakanth; Dou, Wenfang; Hoppensteadt, Debra Moorman; Sparkenbaugh, Erica M.; Cooley, Brian; Daily, Sharon; Key, Nigel S.; Severynse-Stevens, Diana; Fareed, Jawed; Linhardt, Robert J.; Pawlinski, Rafal; Liu, Jian (American Association for the Advancement of Science (AAAS), 2017-09-06)
      Low-molecular weight heparin (LMWH) is used clinically to treat clotting disorders. As an animal-sourced product, LMWH is a highly heterogeneous mixture, and its anticoagulant activity is not fully reversible by protamine. ...