Browsing Linhardt Research Labs Papers by Author "Galliher, P.M."

Now showing items 1-4 of 4

    • A System for Heparin Removal 

      Langer, R.; Linhardt, Robert J.; Klein, M.; Galliher, P.M.; Cooney C.L.; Flanagan, M.M. (1982)
      Extracorporeal medical machines rely on systemic heparinization to improve blood compatibility. However, heparin can lead to serious complications such as hemorrhaging. We propose a new approach to control heparin levels ...

    • Blood Deheparinization Using Immobilized Microbial Heparinase 

      Linhardt, Robert J.; Langer, R.; Cooney, C.L.; Galliher, P.M.; Flanagan, M.M.; Hoffberg, S.M. (Canadian Society for Chemical Engineering, 1981)
      Extracorporeal medical machines (e.g., artificial kidney, pump-oxygenator) perfused with blood have been an effective part of the therapeutic armamentarium for many years. These devices all rely on systemic heparinization ...

    • Heparinase Production by Flavobacterium heparinum 

      Galliher, P.M.; Cooney, C.L.; Langer R.; Linhardt, Robert J. (1981)
      Heparinase production by Flavobacterium heparinum in complex protein digest medium, with heparin employed as the inducer, has been studied and improved. The maximum productivity of heparinase has been increased 156-fold ...

    • The Regulation of Heparinase Production in Flavobacterium heparinum 

      Galliher, P.M.; Linhardt, Robert J.; Conway, L.J.; Langer, R.; Cooney, C.L. (1982)
      The effect of various carbon, nitrogen and sulfur sources on the production of heparinase by Flavobacterium heparinum in defined medium in the presence and absence of heparin as the inducer has been studied. Carbon catabolite ...