Browsing Linhardt Research Labs Papers by Author "Haeger, Sarah M."

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    • Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis potentially impacting cognitive functions 

      Zhang, Xing; Han, Xiaorui; Xia, Ke; Xu, Yongmei; Yang, Yimu; Oshima, Kaori; Haeger, Sarah M.; Perez, Mario J.; McMurtry, Sarah A.; Hippensteel, Joseph A.; Ford, Joshay A.; Herson, Paco S.; Liu, Jian; Schmidt, Eric P.; Linhardt, Robert J. (2019-05-07)
      Sepsis induces heparanase-mediated degradation of the endothelial glycocalyx, a heparan sulfate-enriched endovascular layer critical to vascular homeostasis, releasing highly sulfated domains of heparan sulfate into the ...

    • Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and is Shed during Lung Injury 

      Haeger, Sarah M.; Liu, Xinyue; Han, Xiaorui; Brennan McNeil, J.; Oshima, Kaori; McMurtry, Sarah A.; Yang, Yimu; Ouyang, Yilan; Zhang, Fuming; Nozik-Grayck, Eva; Zemans, Rachel L.; Tuder, Rubin M.; Bastarache, Julie A.; Linhardt, Robert J.; Schmidt, Eric P. (2018-09-01)
      The lung epithelial glycocalyx is a carbohydrate-enriched layer lining the pulmonary epithelial surface. Although epithelial glycocalyx visualization has been reported, its composition and function remain unknown. Using ...

    • Fibroblast growth factor signaling mediates pulmonary endothelial glycocalyx reconstitution 

      Yang, Yimu; Haeger, Sarah M.; Suflita, Matthew A.; Zhang, Fuming; Dailey, Kyrie L.; Colbert, James F.; Ford, Joshay A.; Picon, Mario A.; Stearman, Robert S.; Lin, Lei; Liu, Xinyue; Han, Xiaorui; Linhardt, Robert J.; Schmidt, Eric P. (2017-06-01)
      The endothelial glycocalyx is a heparan sulfate (HS)-rich endovascular structure critical to endothelial function. Accordingly, endothelial glycocalyx degradation during sepsis contributes to tissue edema and organ injury. ...

    • Loss of endothelial sulfatase-1 after experimental sepsis attenuates subsequent pulmonary inflammatory responses 

      Oshima, Kaori; Han, Xiaorui; Ouyang, Yilan; Masri, Rana El; Yang, Yimu; Haeger, Sarah M.; McMurtry, Sarah A.; Lane, Trevor C.; Davizon-Castillo, Pavel; Zhang, Fuming; Yue, Xinping; Vivès, Romain R.; Linhardt, Robert J.; Schmidt, Eric P. (2019-01-01)
      Sepsis patients are at increased risk for hospital-acquired pulmonary infections, potentially due to postseptic immunosuppression known as the compensatory anti-inflammatory response syndrome (CARS). CARS has been attributed ...