Browsing Linhardt Research Labs Papers by Author "Hales, C.A."

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Effect of Fully Sulfated Glycosaminoglycans on Pulmonary ArterySmooth Muscle Cell Proliferation

Garg, H.G.; Joseph, P.A.M.; Thompson, T.; Hales, C.A.; Toida, T.; Imanari, T.; Capila, I.; Linhardt, Robert J. (1999)

Fully sulfated heparin and other glycosaminoglycans, namely heparan, chondroitin, and dermatan sulfates, and hyaluronan have been prepared by using sulfur trioxide under mild chemical conditions. All these derivatives were ...
Heparin as a Potential Therapeutic Agent to Reverse Vascular Remodeling

Garg, H.; Thompson, B.T.; Linhardt, Robert J.; Hales, C.A. (2003)

Vascular changes after chronic hypoxia are characterized by hyperplasia, hypertrophy, and migration of smooth muscle cells (SMCs) in the media of muscular and partially muscular pulmonary arteries (1,2). A number of factors ...
Significance of 2-O-Sulfonate Group of L-Iduronic Acid Residues in Heparin on the Growth Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells

Garg, H.G.; Mrabat, H.; Yu, L.; Freeman, C.; Li, B.; Zhang, F.; Linhardt, Robert J.; Hales, C.A. (Elsevier, 2008)

Heparin inhibits the growth of several cell types in vitro, including bovine pulmonary artery smooth muscle cells (BPASMCs). To understand more about the heparin structure required for endogenous activity, chemically ...