Browsing Linhardt Research Labs Papers by Author "Hales, Charles A."
Now showing items 1-8 of 8
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Anti-proliferative effects of O-acyl-low-molecular-weight heparin derivatives on bovine pulmonary artery smooth muscle cells
Garg, Hari G.; Mrabat, Hicham; Yu, Lunyin; Hales, Charles A.; Li, Boyangzi; Moore, Casey N.; Zhang, Fuming; Linhardt, Robert J. (Springer, 2011-08-01)Heparin (HP) inhibits the growth of several cell types in vitro including bovine pulmonary artery (BPA) smooth muscle cells (SMCs). In initial studies we discovered that an O-hexanoylated low-molecular-weight (LMW) HP ... -
Antitumor effect of butanoylated heparin with low anticoagulant activity on lung cancer growth in mice and rats
Yu, Lunyin; Garg, Hari G.; Li, Boyangzi; Linhardt, Robert J.; Hales, Charles A. (2010-03-01)Whole unfractionated heparin can modestly decrease tumor growth, but the dose of heparin is limited by its anticoagulant properties. To overcome this limitation, we modified the chemical structure of heparin and have ... -
Chemistry and Biology of Heparin and Heparan Sulfate
Garg, Hari G.; Linhardt, Robert J.; Hales, Charles A. (2005-01-01)The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry ... -
Effect of Carboxyl-Reduced Heparin on the Growth Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells
Garg, Hari G.; Mrabat, Hicham; Yu, Lunyin; Freeman, Craig; Li, Boyangzi; Zhang, Fuming; Linhardt, Robert J.; Hales, Charles A. (Elsevier, 2010-06-16)Heparin (HP) inhibits the proliferation of bovine pulmonary artery smooth muscle cells (BPASMC's), among other cell types in vitro. In order to develop a potential therapeutic agent to reverse vascular remodeling, we are ... -
Heparin Oligosaccharide Sequence and Size Essential for Inhibition of Pulmonary Artery Smooth Muscle Cell Proliferation
Garg, Hari G.; Cindhuchao, Naiyaratana; Quinn, Deborah A.; Hales, Charles A.; Thanawiroon, Charuwan; Capila, Ishan; Linhardt, Robert J. (2002-11-19)Heparin has a wide range of important biological activities including inhibition of pulmonary artery smooth muscle cell proliferation. To determine the minimum size of the heparin glycosaminoglycan chain essential for ... -
Increase in the Growth Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells by an O-Hexanoyl Low Molecular Weight Heparin Derivative
Garg, Hari G.; Hales, Charles A.; Yu, Lunyin; Butler, Melissa; Islam, Tasneem; Xie, Jin; Linhardt, Robert J. (Elsevier, 2006-11-06)Proliferation of pulmonary artery smooth muscle cells (PASMCs) appears to play a significant role in chronic pulmonary hypertension. The proliferation of PASMCs is strongly inhibited by some commercial heparin preparations. ... -
Influence of Heparin Chemical Modifications on Its Antiproliferative Properties
Garg, Hari G.; Linhardt, Robert J.; Hales, Charles A. (2005-12-01)This chapter focuses on the mechanisms contributing to heparin inhibition of smooth muscle cell growth. Chronic pulmonary hypertension is characterized by structural changes in the pulmonary vasculature, which along with ... -
Sulfation Patterns in Heparin and Heparan Sulfate: Effects on the Proliferation of Bovine Pulmonary Artery Smooth Muscle Cells
Garg, Hari G.; Yu, Lunyin; Hales, Charles A.; Toida, Toshihiko; Islam, Tasneem; Linhardt, Robert J. (2003-11-20)Heparin's (HP's) antiproliferative effect on smooth muscle cells is potentially important in defining new approaches to treat pulmonary hypertension. The commercially available HP and heparan sulfate (HS) are structurally ...