Browsing Linhardt Research Labs Papers by Author "Han, X."
Now showing items 1-7 of 7
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Alveolar heparan sulfate shedding impedes recovery from bleomycin-induced lung injury
LaRiviere, W. B.; Liao, S.; McMurtry, S. A.; Oshima, K.; Han, X.; Zhang, F.; Yan, S.; Haeger, S. M.; Ransom, M.; Bastarache, J. A.; Linhardt, R. J.; Schmidt, E. P.; Yang, Y. (2020-06-01)The pulmonary epithelial glycocalyx, an anionic cell surface layer enriched in glycosaminoglycans such as heparan sulfate and chondroitin sulfate, contributes to the alveolar barrier. Direct injury to the pulmonary epithelium ... -
Compositional and structural analysis of glycosaminoglycans in cell-derived extracellular matrices
Silva, J.C.; Carvalho, M.S.; Han, X.; Xia, K.; Mikael, P.E.; Cabral, J.M.S.; Castelo Ferreira, F.; Linhardt, Robert J. (Springer, 2019-04-15)The extracellular matrix (ECM) is a highly dynamic and complex meshwork of proteins and glycosaminoglycans (GAGs) with a crucial role in tissue homeostasis and organization not only by defining tissue architecture and ... -
Decline in arylsulfatase B (N-acetylgalactosamine-4-sulfatase) leads to increased EGFR expression due to SHP2 inhibition and JNK activation in prostate
Bhattacharyya, S.; Feferman, L.; Han, X.; Ouya, Y.; Zhang, F.; Linhardt, Robert J.; Tobacman, J.K. (The American Society for Biochemistry and Molecular Biology (ASBMB) and Elsevier, 2018)Epidermal growth factor receptor (EGFR) has a crucial role in cell differentiation and proliferation and cancer, and its expression appears to be up-regulated when arylsulfatase B (ARSB or GalNAc-4-sulfatase) is reduced. ... -
Glycosaminoglycan remodeling during chondrogenic differentiation of human bone marrow−/synovial-derived mesenchymal stem/stromal cells under normoxia and hypoxia
Silva, J.C.; Han, X.; Silva, T.P.; Xia, K.; Mikael, P.E.; Cabral, J.M.S.; Ferreira, F.C.; Linhardt, Robert J. (2020-06-01)Glycosaminoglycans (GAGs) are major components of cartilage extracellular matrix (ECM), which play an important role in tissue homeostasis not only by providing mechanical load resistance, but also as signaling mediators ... -
Increased CHST15 Expression follows Decline in Arylsulfatase B (ARSB) and Disinhibition of Non-Canonical WNT Signaling: Potential for Epithelial-Mesenchymal Transition
Bhattacharyya, S.; Feferman, L.; Han, X.; Xia, K.; Zhang, F.; Linhardt, Robert J.; Tobacman, J.K. (Impact Journals, 2020)Expression of CHST15 (carbohydrate sulfotransferase 15; chondroitin 4-sulfate-6-sulfotransferase; BRAG), the sulfotransferase enzyme that adds 6-sulfate to chondroitin 4-sulfate (C4S) to make chondroitin 4,6-disulfate ... -
On-line CE-LIF-MS analysis of glycans labeled with teal fluorescence dye using electrokinetic sheath liquid pump-based nanospray ion source
Khan, S.; Szabo, Z.; Liu, J.; Kunnummal, B.; Han, X.; Ouyang, Y.; Linhardt, Robert J.; Xia, Q. (2018)Rationale: N-linked glycan analysis of recombinant therapeutic proteins, such as monoclonal antibodies, Fc-fusion proteins, and antibody-drug conjugates, provides valuable information regarding protein therapeutics ... -
The effect of electrospun scaffolds on the glycosaminoglycan profile of differentiating neural stem cells
Garrudo, F.F.F.; Mikael, P.E.; Xia, K.; Silva, J.C.; Ouyang, Y.; Chapman, C.A.; Hoffman, P.R.; Yu, Y.; Han, X.; Rodrigues, C.A.V.; Cabral, J.M.S.; Morgado, J.; Ferreir F.C.; Linhardt, Robert J. (Elsevier, 2021-03-01)The use of electrospun scaffolds for neural tissue engineering applications allows a closer mimicry of the native tissue extracellular matrix (ECM), important for the transplantation of cells in vivo. Moreover, the role ...