Browsing Linhardt Research Labs Papers by Author "Iatridis, James C."

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Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability

Purmessur, Devina; Cornejo, Marisa C.; Cho, Samuel K.; Roughley, Peter J.; Linhardt, Robert J.; Hecht, Andrew C.; Iatridis, James C. (Elsevier, 2015-05-01)

Background context: Painful human intervertebral discs (IVDs) exhibit nerve growth deep into the IVD. Current treatments for discogenic back pain do not address the underlying mechanisms propagating pain and are often ...
A method for characterizing human intervertebral disc glycosaminoglycan disaccharides using liquid chromatography- mass spectrometry with multiple reaction monitoring

Liu, X.; Krishnamoorthy, D.; Lin, L.; Xue, P.; Zhang, F.; Chi, L.; Iatridis, James C. (AO Research Institute Davos, 2018-01-01)

Intervertebral disc (IVD) degeneration results in the depletion of proteoglycans and glycosaminoglycans (GAGs), which can lead to structural and mechanical loss of IVD function, ingrowth of nociceptive nerve fibres and ...