Now showing items 1-2 of 2

    • Ischemic stroke disrupts the endothelial glycocalyx through activation of proHPSE via acrolein exposure 

      Ko, Kenta; Suzuki, Takehiro; Ishikawa, Ryota; Hattori, Natsuko; Ito, Risako; Umehara, Kenta; Furihata, Tomomi; Dohmae, Naoshi; Linhardt, Robert J.; Igarashi, Kazuei; Toida, Toshihiko; Higashi, Kyohei (The American Society for Biochemistry and Molecular Biology (ASBMB) and Elsevier, 2020-12-25)
      Infiltration of peripheral immune cells after blood-brain barrier dysfunction causes severe inflammation after a stroke. Although the endothelial glycocalyx, a network of membrane-bound glycoproteins and proteoglycans that ...
    • Poly-ion Complex of Chondroitin Sulfate and Spermine and its Effect on Oral Chondroitin Sulfate Bioavailability 

      Ge, Dan; Higashi, Kyohei; Ito, Daichi; Nagano, Kenichi; Ishikawa, Ryota; Terui, Yusuke; Higashi, Kenjirou; Moribe, Kunikazu; Linhardt, Robert J.; Toida, Toshihiko (2016-01-01)
      Chondroitin sulfate (CS) has been accepted as an ingredient in health foods for the treatment of symptoms related to arthritis and cartilage repair. However, CS is poorly absorbed through the gastrointestinal tract because ...