Browsing Linhardt Research Labs Papers by Author "Jeske, Walter"

Now showing items 1-7 of 7

    • Analysis of heparins derived from bovine tissues and comparison to porcine intestinal heparins 

      St Ange, Kalib; Onishi, Akihiro; Fu, Li; Sun, Xiaojun; Lin, Lei; Mori, Daisuke; Zhang, Fuming; Dordick, Jonathan S.; Fareed, Jawed; Hoppensteadt, Debra; Jeske, Walter; Linhardt, Robert J. (2016-09-01)
      Heparin is a widely used clinical anticoagulant. It is also a linear glycosaminoglycan with an average mass between 10 and 20 kDa and is primarily made up of trisulfated disaccharides comprised of 1,4-linked iduronic acid ...

    • Chemometric analysis of porcine, bovine and ovine heparins 

      Ouyang, Yilan; Han, Xiaorui; Yu, Yanlei; Chen, Jianle; Fu, Li; Zhang, Fuming; Linhardt, Robert J.; Fareed, Jawed; Hoppensteadt, Debra; Jeske, Walter; Kouta, Ahmed; Zhang, Zhenqing; Xia, Ke (2019-02-05)
      Heparin is a polysaccharide anticoagulant drug isolated from animal tissues. There have been concerns on the safety and security of the heparin supply chain since 2007-8 when a contamination crisis led to its disruption. ...

    • Comparison of low molecular weight heparins prepared from bovine heparins with enoxaparin 

      Liu, Xinyue; Stange, Kalib; Fareed, Jawed; Hoppensteadt, Debra; Jeske, Walter; Kouta, Ahmed; Chi, Lianli; Jin, Caijuan; Jin, Yongsheng; Yao, Yiming; Linhardt, Robert J. (Sage, 2017-09-01)
      Currently porcine intestine is the only approved source for producing pharmaceutical heparin in most countries. Enoxaparin, prepared by benzylation and alkaline depolymerization from porcine intestine heparin, is prevalent ...

    • Comparison of low-molecular-weight heparins prepared from ovine heparins with enoxaparin 

      Chen, Jianle; Yu, Yanlei; Fareed, Jawed; Hoppensteadt, Debra; Jeske, Walter; Kouta, Ahmed; Jin, Caijuan; Jin, Yongsheng; Yao, Yiming; Xia, Ke; Zhang, Fuming; Chen, Shiguo; Ye, Xingqian; Linhardt, Robert J. (Sage, 2019-04-12)
      Heparin and its low-molecular-weight heparin derivatives are widely used clinical anticoagulants. These drugs are critical for the practice of medicine in applications, including kidney dialysis, cardiopulmonary bypass, ...

    • Molecular and biochemical profiling of a heparin-derived oligosaccharide, C3 

      Ma, Qing; Dudas, Bertalan; Daud, Asif; Iqbal, Omer; Hoppensteadt, Debra; Jeske, Walter; Cornelli, Umberto; Lee, John; Lorens, Stanley; Mervis, Ronald; Hanin, Israel; Capila, Ishan; Linhardt, Robert; Fareed, Jawed (2002-02-15)
      This study was designed to characterize a heparin-derived oligosaccharide (HDO), C3, using chemical and biochemical methods. Although previous studies have suggested C3 as a promising compound in the treatment of Alzheimer's ...

    • Molecular Weight Dependent Tissue Factor Pathway Inhibitor Release by Heparin and Heparin Oligosaccharides 

      Ma, Qing; Tobu, Mahmut; Schultz, Christopher; Jeske, Walter; Hoppensteadt, Debra; Walenga, Jeanine; Cornelli, Umberto; Lee, John; Linhardt, Robert J.; Hanin, Israel; Fareed, Jawed (Elsevier, 2007-02-28)
      Heparin and low molecular weight heparins exert their vascular effects by mobilizing tissue factor pathway inhibitor (TFPI) from the vascular endothelium into the blood circulation. We compared the influence of molecular ...

    • Potential anti-SARS-CoV-2 activity of pentosan polysulfate and mucopolysaccharide polysulfate 

      Zhang, Fuming; He, Peng; Rodrigues, Andre L.; Jeske, Walter; Tandon, Ritesh; Bates, John T.; Bierdeman, Michael A.; Fareed, Jawed; Dordick, Jonathan; Linhardt, Robert J. (Multidisciplinary Digital Publishing Institute (MDPI), 2022-02-01)
      With the increased prevalence of new SARS-CoV-2 variants of concern, such as Delta and Omicron, the COVID-19 pandemic has become an ongoing human health disaster, killing millions worldwide. SARS-CoV-2 invades its host ...