Browsing Linhardt Research Labs Papers by Author "Kailemia, Muchena J."
Now showing items 1-3 of 3
-
Complete mass spectral characterization of a synthetic ultralow molecular weight heparin using collision induced dissociation
Kailemia, Muchena J.; Li, Lingyun; Ly, Mellisa; Linhardt, Robert J.; Amster, I. Jonathan (American Chemical Society (ACS), 2012-07-03)Glycosaminoglycans (GAGs) are a class of biologically important molecules, and their structural analysis is the target of considerable research effort. Advances in tandem mass spectrometry (MS/MS) have recently enabled the ... -
Differentiating chondroitin sulfate glycosaminoglycans using collision-induced dissociation; uronic acid cross-ring diagnostic fragments in a single stage of tandem mass spectrometry
Kailemia, Muchena J.; Patel, Anish B.; Johnson, Dane T.; Li, Lingyun; Linhardt, Robert J.; Jonathan Amster, I. (Sage, 2015-06-07)The stereochemistry of the hexuronic acid residues of the structure of glycosaminoglycans (GAGs) is a key feature that affects their interactions with proteins and other biological functions. Electron-based tandem mass ... -
High-field asymmetric-waveform ion mobility spectrometry and electron detachment dissociation of isobaric mixtures of glycosaminoglycans
Kailemia, Muchena J.; Park, Melvin; Kaplan, Desmond A.; Venot, Andre; Boons, Geert Jan; Li, Lingyun; Linhardt, Robert J.; Amster, I. Jonathan (American Chemical Society (ACS), 2014-02-01)High-field asymmetric waveform ion mobility spectrometry (FAIMS) is shown to be capable of resolving isomeric and isobaric glycosaminoglycan negative ions and to have great utility for the analysis of this class of molecules ...