Browsing Linhardt Research Labs Papers by Author "Kannan, Akaash"

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    • Regulation of PTP1B activation through disruption of redox-complex formation 

      Londhe, Avinash D.; Bergeron, Alexandre; Curley, Stephanie M.; Zhang, Fuming; Rivera, Keith D.; Kannan, Akaash; Coulis, Gérald; Rizvi, Syed H.M.; Kim, Seung Jun; Pappin, Darryl J.; Tonks, Nicholas K.; Linhardt, Robert J.; Boivin, Benoit (Nature, 2020-02-01)
      We have identified a molecular interaction between the reversibly oxidized form of protein tyrosine phosphatase 1B (PTP1B) and 14-3-3ζ that regulates PTP1B activity. Destabilizing the transient interaction between 14-3-3ζ ...