Browsing Linhardt Research Labs Papers by Author "Nairn, Alison V."

Now showing items 1-4 of 4

    • A mutant cell library for systematic analysis of heparan sulfate 

      Qiu, Hong; Shi, Songshan; Yue, Jingwen; Xin, Meng; Nairn, Alison V.; Lin, Lei; Liu, Xinyue; Li, Guoyun; Archer-Hartmann, Stephanie A.; Dela Rosa, Mitche; Galizzi, Melina; Wang, Shunchun; Zhang, Fuming; Azadi, Parastoo; van Kuppevelt, Toin H.; Cardoso, Wellington V.; Kimata, Koji; Ai, Xingbin; Moremen, Kelley W.; Esko, Jeffrey D.; Linhardt, Robert J.; Wang, Lianchun (Nature, 2018-11-01)
      Heparan sulfate (HS) is a complex linear polysaccharide that modulates a wide range of biological functions. Elucidating the structure–function relationship of HS has been challenging. Here we report the generation of an ...

    • Changes in glycosaminoglycan structure on differentiation of human embryonic stem cells towards mesoderm and endoderm lineages 

      Gasimli, Leyla; Hickey, Anne Marie; Yang, Bo; Li, Guoyun; Dela Rosa, Mitche; Nairn, Alison V.; Kulik, Michael J.; Dordick, Jonathan S.; Moremen, Kelley W.; Dalton, Stephen; Linhardt, Robert J. (Elsevier, 2014-01-01)
      Background: Proteoglycans are found on the cell surface and in the extracellular matrix, and serve as prime sites for interaction with signaling molecules. Proteoglycans help regulate pathways that control stem cell fate, ...

    • Glycomics of Proteoglycan Biosynthesis in Murine Embryonic Stem Cell Differentiation 

      Nairn, Alison V.; Kinoshita-Toyoda, Akiko; Toyoda, Hidenao; Xie, Jin; Harris, Kyle; Dalton, Stephen; Kulik, Michael; Pierce, J. Michael; Toida, Toshihiko; Moremen, Kelley W.; Linhardt, Robert J. (American Chemical Society (ACS), 2007-11-01)
      Glycosaminoglycans (GAGs) play a critical role in binding and activation of growth factors involved in cell signaling critical for developmental biology. The biosynthetic pathways for GAGs have been elucidated over the ...

    • Structural remodeling of proteoglycans on retinoic acid-induced differentiation of NCCIT cells 

      Gasimli, Leyla; Stansfield, Hope E.; Nairn, Alison V.; Liu, Haiying; Paluh, Janet L.; Yang, Bo; Dordick, Jonathan S.; Moremen, Kelley W.; Linhardt, Robert J. (Springer, 2013-07-01)
      Pluripotent and multipotent cells become increasingly lineage restricted through differentiation. Alterations to the cellular proteoglycan composition and structure should accompany these changes to influence cell ...