Browsing Linhardt Research Labs Papers by Author "Pagadala, Vijayakanth"

Now showing items 1-4 of 4

    • Construction of heparan sulfate microarray for investigating the binding of specific saccharide sequences to proteins 

      Horton, Maurice; Su, Guowei; Yi, Lin; Wang, Zhangjie; Xu, Yongmei; Pagadala, Vijayakanth; Zhang, Fuming; Zaharoff, David A.; Pearce, Ken; Linhardt, Robert J.; Liu, Jian (2021-03-01)
      Heparan sulfate (HS) is a heterogeneous, extracellular glycan that interacts with proteins and other molecules affecting many biological processes. The specific binding motifs of HS interactions are of interest, but have ...

    • Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure 

      Arnold, Katelyn; Xu, Yongmei; Sparkenbaugh, Erica M.; Li, Miaomiao; Han, Xiaorui; Zhang, Xing; Xia, Ke; Piegore, Mark; Zhang, Fuming; Zhang, Xiaoxiao; Henderson, Mike; Pagadala, Vijayakanth; Su, Guowei; Tan, Lisi; Park, Pyong Woo; Stravitz, Richard T.; Key, Nigel S.; Linhardt, Robert J.; Pawlinski, Rafal; Xu, Ding; Liu, Jian (American Association for the Advancement of Science (AAAS), 2020-03-18)
      Acetaminophen/paracetamol (APAP) overdose is the leading cause of drug-induced acute liver failure (ALF) in the United States and Europe. The progression of the disease is attributed to sterile inflammation induced by the ...

    • N-glycans released from glycoproteins using a commercial kit and comprehensively analyzed with a hypothetical database 

      Zhang, Xing; Pagadala, Vijayakanth; Jester, Hannah M.; Lim, Andrew M.; Pham, Truong Quang; Goulas, Anna Marie P.; Liu, Jian; Linhardt, Robert J. (Royal Society of Chemistry, 2017)
      Heparan sulfate (HS) is a member of the glycosaminoglycans (GAG) family that plays essential roles in biological processes from animal sources. Heparin, a highly sulfated form of HS, is widely used as anticoagulant drug ...

    • Synthetic oligosaccharides can replace animal-sourced low-molecular weight heparins 

      Xu, Yongmei; Chandarajoti, Kasemsiri; Zhang, Xing; Pagadala, Vijayakanth; Dou, Wenfang; Hoppensteadt, Debra Moorman; Sparkenbaugh, Erica M.; Cooley, Brian; Daily, Sharon; Key, Nigel S.; Severynse-Stevens, Diana; Fareed, Jawed; Linhardt, Robert J.; Pawlinski, Rafal; Liu, Jian (American Association for the Advancement of Science (AAAS), 2017-09-06)
      Low-molecular weight heparin (LMWH) is used clinically to treat clotting disorders. As an animal-sourced product, LMWH is a highly heterogeneous mixture, and its anticoagulant activity is not fully reversible by protamine. ...