Now showing items 1-3 of 3

    • Control of the heparosan N-deacetylation leads to an improved bioengineered heparin 

      Wang, Zhenyu; Yang, Bo; Zhang, Zhenqing; Ly, Mellisa; Takieddin, Majde; Mousa, Shaker; Liu, Jian; Dordick, Jonathan S.; Linhardt, Robert J. (Springer, 2011-07-01)
      The production of the anticoagulant drug heparin from non-animal sources has a number of advantages over the current commercial production of heparin. These advantages include better source material availability, improved ...
    • Impact of autoclave sterilization on the activity and structure of formulated heparin 

      Beaudet, Julie M.; Weyers, Amanda; Solakyildirim, Kemal; Yang, Bo; Takieddin, Majde; Mousa, Shaker; Zhang, Fuming; Linhardt, Robert J. (Elsevier, 2011-01-01)
      The stability of a formulated heparin was examined during its sterilization by autoclaving. A new method to follow loss in heparin binding to the serine protease inhibitor, antithrombin III, and the serine protease, thrombin, ...
    • Pharmacokinetics and Pharmacodynamics of Oral Heparin Solid Dosage Form in Healthy Human Subjects 

      Mousa, Shaker A.; Fuming Zhang,; Aljada, Ahmad; Chaturvedi, Seema; Takieddin, Majde; Haifeng Zhang,; Lianli Chi,; Cristina Castelli, M.; Friedman, Kristen; Goldberg, Michael M.; Linhardt, Robert J. (American College of Clinical Pharmacology (ACCP), 2007-12-01)
      The present investigation determined the molecular structure and the pharmacokinetic and pharmacodynamic profiles of oral unfractionated heparin containing oral absorption enhancer sodium N-[8-(2-hydroxybenzoyl) amino]caprylate, ...