Now showing items 1-6 of 6

    • Anti-SARS-CoV-2 activity of rhamnan sulfate from Monostroma nitidum 

      Song, Yuefan; He, Peng; Rodrigues, Andre L.; Datta, Payel; Tandon, Ritesh; Bates, John T.; Bierdeman, Michael A.; Chen, Chen; Dordick, Jonathan; Zhang, Fuming; Linhardt, Robert J. (Multidisciplinary Digital Publishing Institute (MDPI), 2021-12-01)
      The COVID-19 pandemic is a major human health concern. The pathogen responsible for COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), invades its host through the interaction of its spike (S) protein ...
    • The degree of polymerization and sulfation patterns in heparan sulfate are critical determinants of cytomegalovirus entry into host cells 

      Mitra, Dipanwita; Hasan, Mohammad H.; Bates, John T.; Bierdeman, Michael A.; Ederer, Dallas R.; Parmar, Rinkuben C.; Fassero, Lauren A.; Liang, Quntao; Qiu, Hong; Tiwari, Vaibhav; Zhang, Fuming; Linhardt, Robert J.; Sharp, Joshua S.; Wang, Lianchun; Tandon, Ritesh (Public Library of Science (PLoS), 2021-08-01)
      Several enveloped viruses, including herpesviruses attach to host cells by initially interacting with cell surface heparan sulfate (HS) proteoglycans followed by specific coreceptor engagement which culminates in virus-host ...
    • Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin derivatives 

      Tandon, Ritesh; Sharp, Joshua S.; Zhang, Fuming; Pomin, Vitor H.; Ashpole, Nicole M.; Mitra, Dipanwita; McCandless, Martin G.; Jin, Weihua; Liu, Hao; Sharma, Poonam; Linhardt, Robert J. (American Society for Microbiology, 2021-02-01)
      Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has caused a pandemic of historic proportions and continues to spread globally, with enormous consequences to human health. Currently there is no vaccine, ...
    • Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus 

      Yan, Lufeng; Song, Yuefan; Xia, Ke; He, Peng; Zhang, Fuming; Chen, Shiguo; Pouliot, Robert; Weiss, Daniel J.; Tandon, Ritesh; Bates, John T.; Ederer, Dallas R.; Mitra, Dipanwita; Sharma, Poonam; Davis, April; Linhardt, Robert J. (2021-05-15)
      Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has resulted in a pandemic and continues to spread at an unprecedented rate around the world. Although a vaccine has recently been approved, there are ...
    • Potential anti-SARS-CoV-2 activity of pentosan polysulfate and mucopolysaccharide polysulfate 

      Zhang, Fuming; He, Peng; Rodrigues, Andre L.; Jeske, Walter; Tandon, Ritesh; Bates, John T.; Bierdeman, Michael A.; Fareed, Jawed; Dordick, Jonathan; Linhardt, Robert J. (Multidisciplinary Digital Publishing Institute (MDPI), 2022-02-01)
      With the increased prevalence of new SARS-CoV-2 variants of concern, such as Delta and Omicron, the COVID-19 pandemic has become an ongoing human health disaster, killing millions worldwide. SARS-CoV-2 invades its host ...
    • The structure-activity relationship of the interactions of SARS-CoV-2 spike glycoproteins with glucuronomannan and sulfated galactofucan from Saccharina japonica 

      Jin, Weihua; Zhang, Wenjing; Mitra, Dipanwita; McCandless, Martin G.; Sharma, Poonam; Tandon, Ritesh; Zhang, Fuming; Linhardt, Robert J. (2020-11-15)
      The SARS-CoV-2 spike glycoproteins (SGPs) and human angiotensin converting enzyme 2 (ACE2) are the two key targets for the prevention and treatment of COVID-19. Host cell surface heparan sulfate (HS) is believed to interact ...