Browsing Linhardt Research Labs Papers by Author "Wang, C."
Now showing items 1-3 of 3
-
Characterization of heparin’s conformational ensemble by molecular dynamics simulations and nuclear magnetic resonance spectroscopy
Janke, J.J.; Yu, Y.; Pomin, Vitor H.; Zhao, J.; Wang, C.; Linhardt, Robert J.; García, A.E. (American Chemical Society (ACS), 2022-03-08)Heparin is a highly charged, polysulfated polysaccharide and serves as an anticoagulant. Heparin binds to multiple proteins throughout the body, suggesting a large range of potential therapeutic applications. Although its ... -
Intrinsically disordered N-terminal domain (NTD) of p53 interacts with mitochondrial PTP regulator Cyclophilin D
Zhao, J.; Liu, X.; Blayney, A.; Zhang, Y.; Gandy, L.; Mirsky, P.O.; Smith, N.; Zhang, F.; Linhardt, Robert J.; Chen, J.; Baines, C.; Loh, S.N.; Wang, C. (Elsevier, 2022)Mitochondrial permeability transition pore (mPTP) plays crucial roles in cell death in a variety of diseases, including ischemia/reperfusion injury in heart attack and stroke, neurodegenerative conditions, and cancer. To ... -
Major differences between the self-assembly and seeding behavior of heparin-induced- and in-vitro-phosphorylated tau and their modulation by potential inhibitors
Despres, C.; Di, J.; Cantrelle, F.X.; Li, Z.; Huvent, I.; Chambraud, B.; Zhao, J.; Chen, J.; Chen, S.; Lippens, G.; Zhang, F.; Linhardt, Robert J.; Wang, C.; Klärner, F.G.; Schrader, T.; Landrieu, I.; Bitan, G.; Smet-Nocca, C. (American Chemical Society (ACS), 2019-06-21)Self-assembly of the microtubule-associated protein tau into neurotoxic oligomers, fibrils, and paired helical filaments, and cell-to-cell spreading of these pathological tau species are critical processes underlying the ...