Browsing Linhardt Research Labs Papers by Author "Wang, Chunyu"

Now showing items 1-10 of 10

    • 3-O-sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake 

      Zhao, Jing; Zhu, Yanan; Song, Xuehong; Xiao, Yuanyuan; Su, Guowei; Liu, Xinyue; Wang, Zhangjie; Xu, Yongmei; Liu, Jian; Eliezer, David; Ramlall, Trudy F.; Lippens, Guy; Gibson, James; Zhang, Fuming; Linhardt, Robert J.; Wang, Lianchun; Wang, Chunyu (Wiley, 2020-01-27)
      Prion-like transcellular spreading of tau in Alzheimer's Disease (AD) is mediated by tau binding to cell surface heparan sulfate (HS). However, the structural determinants for tau-HS interaction are not well understood. ...

    • Circadian Control of Heparan Sulfate Levels Times Phagocytosis of Amyloid Beta Aggregates 

      Clark, Gretchen T.; Yu, Yanlei; Urban, Cooper A.; Fu, Guo; Wang, Chunyu; Zhang, Fuming; Linhardt, Robert J.; Hurley, Jennifer M. (Public Library of Science (PLoS), 2022-02-10)
      Alzheimer’s Disease (AD) is a neuroinflammatory disease characterized partly by the inability to clear, and subsequent build-up, of amyloid-beta (Aβ). AD has a bi-directional relationship with circadian disruption (CD) ...

    • Glycan Determinants of Heparin-Tau Interaction 

      Zhao, Jing; Huvent, Isabelle; Lippens, Guy; Eliezer, David; Zhang, Anqiang; Li, Quanhong; Tessier, Peter; Linhardt, Robert J.; Zhang, Fuming; Wang, Chunyu (2017-03-14)
      Tau aggregates into paired helical filaments within neurons, a pathological hallmark of Alzheimer's disease. Heparin promotes tau aggregation and recently has been shown to be involved in the cellular uptake of tau aggregates. ...

    • Homogalacturonan from squash: Characterization and tau-binding pattern of a sulfated derivative 

      Zhang, Yu; Liu, Panhang; Wang, Chunyu; Zhang, Fuming; Linhardt, Robert J.; Eliezer, David; Li, Quanhong; Zhao, Jing (2022-06-01)
      A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra. Sulfation modification of ...

    • Intein-promoted cyclization of aspartic acid flanking the intein leads to atypical N-terminal cleavage 

      Minteer, Christopher J.; Siegart, Nicolle M.; Colelli, Kathryn M.; Liu, Xinyue; Linhardt, Robert J.; Wang, Chunyu; Gomez, Alvin V.; Reitter, Julie N.; Mills, Kenneth V. (2017-02-28)
      Protein splicing is a post-translational reaction facilitated by an intein, or intervening protein, which involves the removal of the intein and the ligation of the flanking polypeptides, or exteins. A DNA polymerase II ...

    • Interactions of Fibroblast Growth Factors with Sulfated Galactofucan from Saccharina japonica 

      Jin, Weihua; Jiang, Di; Zhang, Wenjing; Wang, Chunyu; Xia, Ke; Zhang, Fuming; Linhardt, Robert J. (2020-10-01)
      A total 68 types of marine algae oligosaccharides and polysaccharides were prepared and used to study the structure-activity relationship of oligosaccharides and polysaccharides in their interactions with fibroblast growth ...

    • Internal disulfide bond acts as a switch for intein activity 

      Nicastri, Michael C.; Xega, Kristina; Li, Lingyun; Xie, Jian; Wang, Chunyu; Linhardt, Robert J.; Reitter, Julie N.; Mills, Kenneth V. (American Chemical Society (ACS), 2013-08-27)
      Inteins are intervening polypeptides that catalyze their own removal from flanking exteins, concomitant to the ligation of the exteins. The intein that interrupts the DP2 (large) subunit of DNA polymerase II from Methanoculleus ...

    • Intramolecular Disulfide Bond between Catalytic Cysteines in an Intein Precursor 

      Chen, Wen; Li, Lingyun; Du, Zhenming; Liu, Jiajing; Reitter, Julie N.; Mills, Kenneth V.; Linhardt, Robert J.; Wang, Chunyu (American Chemical Society (ACS), 2012-02-08)
      Protein splicing is a self-catalyzed and spontaneous post-translational process in which inteins excise themselves out of precursor proteins while the exteins are ligated together. We report the first discovery of an ...

    • Structural analysis of a glucoglucuronan derived from laminarin and the mechanisms of its anti-lung cancer activity 

      Jin, Weihua; He, Xinyue; Wu, Wanli; Bao, Yizhong; Wang, Sanying; Cai, Min; Zhang, Wenjing; Wang, Chunyu; Zhang, Fuming; Linhardt, Robert J.; Mao, Genxiang; Zhong, Weihong (2020-11-15)
      Laminarin (LA), a storage glucan, was purified from the brown alga Sargassum thunbergii. After specific oxidation using the stable nitroxyl radical, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), together with NaBr and ...

    • The sulfation code of tauopathies: heparan sulfate proteoglycans in the prion like spread of tau pathology 

      Mah, Dylan; Zhao, Jing; Liu, Xinyue; Zhang, Fuming; Liu, Jian; Wang, Lianchun; Linhardt, Robert J.; Wang, Chunyu (Frontiers Media SA, 2021-05-20)
      Tauopathies are a heterogenous family of progressive neurodegenerative diseases defined by the appearance of proteinaceous lesions within the brain composed of abnormally folded species of Microtubule Associated Protein ...