Browsing Linhardt Research Labs Papers by Author "Wang, Danli"

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Molecular size is important for the safety and selective inhibition of intrinsic factor Xase for fucosylated chondroitin sulfate

Yan, Lufeng; Li, Junhui; Wang, Danli; Ding, Tian; Hu, Yaqin; Ye, Xingqian; Linhardt, Robert J.; Chen, Shiguo (2017-12-15)

Fucosylated chondroitin sulfate from sea cucumber Isostichopus badionotus (FCS-Ib) showed potent anticoagulant activities without selectivity. The present study focused on developing safe FCS-Ib oligomers showing selective ...
Oral administration of fucosylated chondroitin sulfate oligomers in gastro-resistant microcapsules exhibits a safe antithrombotic activity

Yan, Lufeng; Zhu, Mengshan; Wang, Danli; Tao, Wenyang; Liu, Donghong; Zhang, Fuming; Linhardt, Robert J.; Ye, Xingqian; Chen, Shiguo (2021-01-01)

Fucosylated chondroitin sulfate (FCS) polysaccharide isolated from sea cucumber has potent anticoagulant activity. Based on its resistance to the enzymes present in vertebrates, it may serve as an anticoagulant and shows ...