Now showing items 1-7 of 7

    • 3-O-sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake 

      Zhao, Jing; Zhu, Yanan; Song, Xuehong; Xiao, Yuanyuan; Su, Guowei; Liu, Xinyue; Wang, Zhangjie; Xu, Yongmei; Liu, Jian; Eliezer, David; Ramlall, Trudy F.; Lippens, Guy; Gibson, James; Zhang, Fuming; Linhardt, Robert J.; Wang, Lianchun; Wang, Chunyu (Wiley, 2020-01-27)
      Prion-like transcellular spreading of tau in Alzheimer's Disease (AD) is mediated by tau binding to cell surface heparan sulfate (HS). However, the structural determinants for tau-HS interaction are not well understood. ...
    • A mutant cell library for systematic analysis of heparan sulfate 

      Qiu, Hong; Shi, Songshan; Yue, Jingwen; Xin, Meng; Nairn, Alison V.; Lin, Lei; Liu, Xinyue; Li, Guoyun; Archer-Hartmann, Stephanie A.; Dela Rosa, Mitche; Galizzi, Melina; Wang, Shunchun; Zhang, Fuming; Azadi, Parastoo; van Kuppevelt, Toin H.; Cardoso, Wellington V.; Kimata, Koji; Ai, Xingbin; Moremen, Kelley W.; Esko, Jeffrey D.; Linhardt, Robert J.; Wang, Lianchun (Nature, 2018-11-01)
      Heparan sulfate (HS) is a complex linear polysaccharide that modulates a wide range of biological functions. Elucidating the structure–function relationship of HS has been challenging. Here we report the generation of an ...
    • Characterization of the interaction between Robo1 and heparin/glycosaminoglycans 

      Zhang, Fuming; Moniz, Heather A.; Walcott, Benjamin; Moremen, Kelley W.; Linhardt, Robert J.; Wang, Lianchun (Elsevier, 2013-12-01)
      Roundabout 1 (Robo1) is the cognate receptor for secreted axon guidance molecule, Slits, which function to direct cellular migration during neuronal development and angiogenesis. The Slit2–Robo1 signaling is modulated by ...
    • The degree of polymerization and sulfation patterns in heparan sulfate are critical determinants of cytomegalovirus entry into host cells 

      Mitra, Dipanwita; Hasan, Mohammad H.; Bates, John T.; Bierdeman, Michael A.; Ederer, Dallas R.; Parmar, Rinkuben C.; Fassero, Lauren A.; Liang, Quntao; Qiu, Hong; Tiwari, Vaibhav; Zhang, Fuming; Linhardt, Robert J.; Sharp, Joshua S.; Wang, Lianchun; Tandon, Ritesh (Public Library of Science (PLoS), 2021-08-01)
      Several enveloped viruses, including herpesviruses attach to host cells by initially interacting with cell surface heparan sulfate (HS) proteoglycans followed by specific coreceptor engagement which culminates in virus-host ...
    • Heparan sulfate facilitates spike protein-mediated SARS-Cov-2 host cell invasion and contributes to increased infection of SARS-Cov-2 G614 mutant and in lung cancer 

      Yue, Jingwen; Jin, Weihua; Yang, Hua; Faulkner, John; Song, Xuehong; Qiu, Hong; Teng, Michael; Azadi, Parastoo; Zhang, Fuming; Linhardt, Robert J.; Wang, Lianchun (Multidisciplinary Digital Publishing Institute (MDPI), 2021-06-11)
      The severe acute respiratory syndrome (SARS)-like coronavirus disease (COVID-19) is caused by SARS-CoV-2 and has been a serious threat to global public health with limited treatment. Cellular heparan sulfate (HS) has been ...
    • Impact of GFP tagging on Robo1-heparin interaction 

      Zhang, Fuming; Moniz, Heather A.; Walcott, Benjamin; Moremen, Kelley W.; Wang, Lianchun; Linhardt, Robert J. (2014-01-01)
      Green fluorescent proteins (GFPs) and their derivatives are widely used as markers to visualize cells, protein localizations in in vitro and in vivo studies. The use of GFP fusion protein for visualization is generally ...
    • The sulfation code of tauopathies: heparan sulfate proteoglycans in the prion like spread of tau pathology 

      Mah, Dylan; Zhao, Jing; Liu, Xinyue; Zhang, Fuming; Liu, Jian; Wang, Lianchun; Linhardt, Robert J.; Wang, Chunyu (Frontiers Media SA, 2021-05-20)
      Tauopathies are a heterogenous family of progressive neurodegenerative diseases defined by the appearance of proteinaceous lesions within the brain composed of abnormally folded species of Microtubule Associated Protein ...