Browsing Linhardt Research Labs Papers by Author "Xia, Qiangwei"
Now showing items 1-4 of 4
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Analysis of heparin oligosaccharides by capillary electrophoresis- negative-ion electrospray ionization mass spectrometry
Lin, Lei; Liu, Xinyue; Zhang, Fuming; Chi, Lianli; Amster, I. Jonathan; Leach, Franklyn E.; Xia, Qiangwei; Linhardt, Robert J. (Springer, 2017-01-01)Most hyphenated analytical approaches that rely on liquid chromatography–MS require relatively long separation times, produce incomplete resolution of oligosaccharide mixtures, use eluents that are incompatible with ... -
Capillary Electrophoresis-Mass Spectrometry for the Analysis of Heparin Oligosaccharides and Low Molecular Weight Heparin
Sun, Xiaojun; Lin, Lei; Liu, Xinyue; Zhang, Fuming; Chi, Lianli; Xia, Qiangwei; Linhardt, Robert J. (2016-02-02)Heparins, highly sulfated, linear polysaccharides also known as glycosaminoglycans, are among the most challenging biopolymers to analyze. Hyphenated techniques in conjunction with mass spectrometry (MS) offer rapid analysis ... -
Heparin/heparan sulfate analysis by covalently modified reverse polarity capillary zone electrophoresis-mass spectrometry
Sanderson, Patience; Stickney, Morgan; Leach, Franklin E.; Xia, Qiangwei; Yu, Yanlei; Zhang, Fuming; Linhardt, Robert J.; Amster, I. Jonathan (Elsevier, 2018-04-13)Reverse polarity capillary zone electrophoresis coupled to negative ion mode mass spectrometry (CZE-MS) is shown to be an effective and sensitive tool for the analysis of glycosaminoglycan mixtures. Covalent modification ... -
Negative-ion mode capillary isoelectric focusing-mass spectrometry for charge-based separation of acidic oligosaccharides
Ouyang, Yilan; Han, Xiaorui; Xia, Qiangwei; Chen, Jianle; Velagapudi, Sheila; Xia, Ke; Zhang, Zhenqing; Linhardt, Robert J. (2019-01-02)Glycosaminoglycans (GAGs) are biologically and pharmacologically important linear, anionic polysaccharides containing various repeating disaccharides sequences. The analysis of these polysaccharides generally relies on ...