Browsing Linhardt Research Labs Papers by Author "Xiao, Zhongping"

Now showing items 1-7 of 7

    • Electron detachment dissociation and infrared multiphoton dissociation of heparin tetrasaccharides 

      Leach, Franklin E.; Xiao, Zhongping; Laremore, Tatiana N.; Linhardt, Robert J.; Amster, I. Jonathan (Elsevier, 2011-12-01)
      Heparin glycosaminoglycans (GAGs) present the most difficult glycoform for analytical characterization due to high levels of sulfation and structural heterogeneity. Recent contamination of the clinical heparin supply and ...

    • Heparin mapping using heparin lyases and the generation of a novel low molecular weight heparin 

      Xiao, Zhongping; Tappen, Britney R.; Ly, Mellisa; Zhao, Wenjing; Canova, Lauren P.; Guan, Huashi; Linhardt, Robert J. (American Chemical Society (ACS), 2011-01-27)
      Seven pharmaceutical heparins were investigated by oligosaccharide mapping by digestion with heparin lyase 1, 2, or 3, followed by high performance liquid chromatography analysis. The structure of one of the prepared mapping ...

    • Mass balance analysis of contaminated heparin product 

      Liu, Zhenling; Xiao, Zhongping; Masuko, Sayaka; Zhao, Wenjing; Sterner, Eric; Bansal, Vinod; Fareed, Jawed; Dordick, Jonathan; Zhang, Fuming; Linhardt Robert J., R. J. (Elsevier, 2011-01-01)
      A quantitative analysis of a recalled contaminated lot of heparin sodium injection U.S. Pharmacopeia (USP) was undertaken in response to the controversy regarding the exact nature of the contaminant involved in the heparin ...

    • Negative electron transfer dissociation Fourier transform mass spectrometry of glycosaminoglycan carbohydrates 

      Leach, Franklin E.; Wolff, Jeremy J.; Xiao, Zhongping; Ly, Mellisa; Laremore, Tatiana N.; Arungundram, Sailaja; Al-Mafraji, Kanar; Venot, Andre; Boons, Geert Jan; Linhardt, Robert J.; Amstera, I. Jonathan (Sage, 2011-01-01)
      Electron transfer through gas-phase ion–ion reactions has led to the widespread application ofelectron-based techniques once only capable in ion trapping mass spectrometers. Although anymass analyzer can, in theory, be ...

    • Structural characterization of heparins from different commercial sources 

      Zhang, Fuming; Yang, Bo; Ly, Mellisa; Solakyildirim, Kemal; Xiao, Zhongping; Wang, Zhenyu; Beaudet, Julie M.; Torelli, Amanda Y.; Dordick, Jonathan S.; Linhardt, Robert J. (Springer, 2011-11-01)
      Seven commercial heparin active pharmaceutical ingredients and one commercial low molecular weight from different manufacturers were characterized with a view profiling their physicochemical properties. All heparins had ...

    • Structural snapshots of heparin depolymerization by heparin lyase I 

      Han, Young Hyun; Garron, Marie Line; Kim, Hye Yeon; Kim, Wan Seok; Zhang, Zhenqing; Ryu, Kyeong Seok; Shaya, David; Xiao, Zhongping; Cheong, Chaejoon; Kim, Yeong Shik; Linhardt, R. J.; Jeon, Young Ho; Cygler, Miroslaw (Elsevier, 2009-12-04)
      Heparin lyase I (heparinase I) specifically depolymerizes heparin, cleaving the glycosidic linkage next to iduronic acid. Here, we show the crystal structures of heparinase I from Bacteroides thetaiotaomicron at various ...

    • Thin Layer Chromatography for the Separation and Analysis of Acidic Carbohydrates 

      Zhang, Zhenqing; Xiao, Zhongping; Linhardt, Robert J. (2009-10-13)
      Thin layer chromatography (TLC) is routinely used by synthetic organic chemists and natural products chemists working on a variety of types of molecules. Carbohydrate chemists and biochemists in the past largely relied on ...