Browsing Linhardt Research Labs Papers by Author "Yang, B."
Now showing items 1-7 of 7
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A structural analysis of glycosaminoglycans from lethal and non-lethal breast cancer tissues: Towards a novel class of theragnostics for personalized medicine in oncology
Weyers, A.; Yang, B.; Yoon, D.S.; Park, J.H.; Zhang, F.; Lee, K.B.; Linhardt, Robert J. (2012)Cancer is one of the leading noncommunicable diseases that vastly impacts both developed and developing countries. Truly innovative diagnostics that inform disease susceptibility, prognosis, and/or response to treatment ... -
Asparagine 405 of heparin lyase II prevents the cleavage of glycosidic linkages proximate to a 3-O-sulfo glucosamine residue
Zhao, W.; Garron, M.L.; Yang, B.; Xiao, Z.; Esko, J.D.; Cygler, M; Linhardt, Robert J. (FEBS Press, 2011)Heparin and heparan sulfate contain a rare 3-O-sulfoglucosamine residue critical for anticoagulation and virus recognition, respectively. The glycosidic linkage proximate to this 3-O-sulfoglucosamine is resistant to cleavage ... -
Disaccharide analysis of glycosaminoglycan mixtures by ultra-performance liquid chromatography-mass spectrometry
Yang, B.; Chang, Y.; Weyers, A.M.; Sterner, E.; Linhardt, Robert J. (Elsevier, 2012)Glycosaminoglycans are a family of polysaccharides widely distributed in all eukaryotic cells. These polyanionic, linear chain polysaccharides are composed of repeating disaccharide units that are often differentially ... -
Heparinase I selectivity for the 3,6-di-O-sulfo-2-deoxy-2-sulfamido-a-D-glucopyranose (1,4) 2-O-sulfo-a-L-idopyranosyluronic acid (GlcNS3S6S-IdoA2S) linkages
Xiao, Z.; Zhao, W.; Yang, B.; Zhang, Z.; Guan, H.; Linhardt, Robert J. (2011)Porcine intestinal mucosa heparin was partially depolymerized by recombinant heparinase 1 (heparin lyase 1, originating from Flavobacterium heparinum and expressed in Escherichia coli) and then fractionated, leading to the ... -
HSulf-1 modulates FGF-2 and hypoxia mediated migration and invasion of breast cancer cells
Khurana, A.; Liu, P.; Mellone, P.; Lorenzon, L.; Vincenzi, B.; Datta, K.; Yang, B.; Linhardt, Robert J.; Lingle, W.; Chien, J.; Baldi, A.; Shridhar, V. (American Association for Cancer Research (AACR), 2011)HSulf-1 modulates the sulfation states of heparan sulfate proteoglycans critical for heparin binding growth factor signaling. In the present study, we show that HSulf-1 is transcriptionally deregulated under hypoxia in ... -
Impact of high salt diet on N-acetylgalactosamine-4-sulfatase activity, glycosaminoglycans, and kininogen in rat kidney
Kotlo, K.; Bhattacharyya, S.; Yang, B.; Tejaskumar, S.; Linhardt, Robert J.; Danziger, R.; Tobacman, J.K. (Springer, 2013)N-acetylgalactosamine-4-sulfatase (Arylsulfatase B; ARSB) is the enzyme that removes sulfate groups from the N-acetylgalactosamine-4-sulfate residue at the non-reducing end of chondroitin-4-sulfate (C4S) and dermatan sulfate ... -
Ultraperformance ion-pairing liquid chromatography with on-line electrospray ion trap mass spectrometry for heparin disaccharide analysis
Yang, B.; Weyers, A.; Baik, J.Y.; Sterner, E.; Sharfstein, S.; Mousa, S.A.; Zhang, F.; Dordick, J.S.; Linhardt, Robert J. (Elsevier, 2011)A high resolution method for the separation and analysis of disaccharides prepared from heparin and heparan sulfate (HS) using heparin lyases is described. Ultraperformance liquid chromatography in a reverse-phase, ion-pairing ...