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    • An Immobilized Microbial Heparinase for Blood Deheparinization 

      Linhardt, R. J.; Cooney, C. L.; Tapper, D.; Zannetos, C. A.; Larsen, A. K.; Langer, R. (1984-02-01)
      A new medical application of an immobilized microbial enzyme is described. Extracorporeal devices require systemic heparin administration to prevent thrombus formation; however, the use of heparin often leads to serious ...