Browsing Linhardt Research Labs Papers by Author "Zhang, F."
Now showing items 1-20 of 69
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The 2.8 Å Electron Microscopy Structure of Adeno-Associated Virus-DJ Bound by a Heparanoid Pentasaccharide
Xie, Q.; Spear, J.; Noble, A.; Sousa, D.; Meyer, N.; Davulcu, O.; Zhang, F.; Stagg, S.; Chapman, M. (Elsevier, 2017)Atomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 Å resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural ... -
A Kinetic Model for FGF, FGFR and Proteoglycan Signal Transduction Complex Assembly
Ibrahimi, O.A.; Zhang, F.; Lang Hrstka, S.C.; Mohammadi, M.; Linhardt, Robert J. (2004)The current working model for fibroblast growth factor receptor (FGFR) dimerization and activation requires the assembly of a ternary complex of fibroblast growth factor (FGF), FGFR, and heparin or heparan sulfate proteoglycan ... -
A structural analysis of glycosaminoglycans from lethal and non-lethal breast cancer tissues: Towards a novel class of theragnostics for personalized medicine in oncology
Weyers, A.; Yang, B.; Yoon, D.S.; Park, J.H.; Zhang, F.; Lee, K.B.; Linhardt, Robert J. (2012)Cancer is one of the leading noncommunicable diseases that vastly impacts both developed and developing countries. Truly innovative diagnostics that inform disease susceptibility, prognosis, and/or response to treatment ... -
Adsorption of doxorubicin on poly(methyl methacrylate)−chitosan−heparin-coated activated carbon beads
Miao, J.; Zhang, F.; Takieddin, M.; Mousa, S.; Linhardt, Robert J. (2012)Extracorporeal filter cartridges, filled with an activated carbon bead (ACB) adsorbent, have been used for removal of overdosed cancer drugs from the blood. Coatings on adsorbent matrices, poly(methyl methacrylate) ... -
Affinity Purification of Secreted Alkaline Phosphatase Produced by the Baculovirus Expression Vector System
Zhang, F.; Wolff, M.W.; Williams, D.; Busch, K.; Lang, S.C.; Murhammer, D.W.; Linhardt, Robert J. (2001-01-01)Human secreted alkaline phosphatase (SEAP) was produced in a stably-transformed Spodoptera frugiperda Sf-9 insect cell line (Sfb4GalT) following infection with a recombinant Autographa californica multiple nuclear ... -
Alveolar heparan sulfate shedding impedes recovery from bleomycin-induced lung injury
LaRiviere, W. B.; Liao, S.; McMurtry, S. A.; Oshima, K.; Han, X.; Zhang, F.; Yan, S.; Haeger, S. M.; Ransom, M.; Bastarache, J. A.; Linhardt, R. J.; Schmidt, E. P.; Yang, Y. (2020-06-01)The pulmonary epithelial glycocalyx, an anionic cell surface layer enriched in glycosaminoglycans such as heparan sulfate and chondroitin sulfate, contributes to the alveolar barrier. Direct injury to the pulmonary epithelium ... -
Analysis of the Biochemical Mechanisms for the Endocrine Actions of FGF23
Yu, X.; Ibrahimi, O.A.; Zhang, F.; Davis, S.I.; Garringer, H.J.; Linhardt, Robert J.; Ornitz, D.M.; Mohammadi, M.; White, K.E. (Oxford, 2005)Fibroblast growth factor (FGF)-23 has emerged as an endocrine regulator of phosphate and of vitamin D metabolism. It is produced in bone and, unlike other FGFs, circulates in the bloodstream to ultimately regulate phosphate ... -
Binding affinities of vascular endothelial growth factor (VEGF) for heparin-derived oligosaccharides
Zhao, W.; McCallum, Scott A.; Xiao, Z.; Zhang, F.; Linhardt, Robert J. (Portland Press, 2012)Heparin and HS (heparan sulfate) exert their wide range of biological activities by interacting with extracellular protein ligands. Among these important protein ligands are various angiogenic growth factors and cytokines. ... -
Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities in human skeletal disorders
Ibrahimi, O.A.; Zhang, F.; Eliseenkova, A.V.; Itoh, N.; Linhardt, Robert J.; Mohammadi, M. (Oxford, 2004)Gain-of-function missense mutations in FGF receptor 2 (FGFR2) are responsible for a variety of craniosynostosis syndromes including Apert syndrome (AS), Pfeiffer syndrome (PS) and Crouzon syndrome (CS). Unlike the majority ... -
Bioengineered production of glycosaminoglycans and their analogues
Jin, W.; Zhang, F.; Linhardt, Robert J. (2021)Glycosaminoglycans (GAGs) are a class of linear polysaccharides, consisting of alternating disaccharide sequences of uronic acid and hexosamines (or galactose) with and without sulfation. They can interact with various ... -
Can natural fibers be a silver bullet? Antibacterial cellulose fibers through covalent bonding of silver nanotparticles to electrospun fibers
Zheng, Y.; Cai, C.; Zhang, F.; Monty, J.; Linhardt, Robert J.; Simmons, T. (2016)Natural cotton was dissolved in a room-temperature ionic liquid 1-ethyl-3-methyl acetate and wet-jet electrospun to obtain nanoscale cotton fibers with a substantially reduced diameter—and therefore an increased surface ... -
Characteristics of global organic matrix in normal and pimpled chicken eggshells
Liu, Z.; Zhang, F.; He, W.; Linhardt, Robert J. (Elsevier, 2017-01-01)The organic matrix from normal and pimpled calcified chicken eggshells were dissociated into acid-insoluble, water-insoluble, and facultative-soluble (both acid- and water-soluble) components, to understand the influence ... -
Characteristics of glycosaminoglycans in chicken eggshells and the influence of disaccharide composition on eggshell properties
Liu, Z.; Sun, X.; Cai, C.; He, W.; Zhang, F. (Elsevier, 2016-01-01)Glycosaminoglycans (GAG) are linear, highly negatively charged polysaccharides that may perform an important role in biomineralization. GAG were isolated from chicken eggshell membranes and calcified shells. Disaccharide ... -
Characterization of Interactions between Heparin/Glycosaminoglycan and Adeno-associated Virus
Zhang, F.; Beaudet, J.M.; Aguilera, J.; Xie, Q.; Lerch, T.F.; Davulcu, O.; Colón, W.; Chapman, M.S.; Linhardt, Robert J. (American Chemical Society (ACS), 2013-09-10)Adeno-associated virus (AAV) is a key candidate in the development of gene therapy. In this work, we used surface plasmon resonance spectroscopy to study the interaction between AAV and heparin and other glycosaminoglycans ... -
Compositional analysis of heparin/heparan sulfate interacting with fibroblast growth factor•fibroblast growth factor receptor complexes
Zhang, F.; Zhang, Z.; Lin, X.; Beenken, A.; Eliseenkova, A.V.; Mohammadi, M.; Linhardt, Robert J. (American Chemical Society (ACS), 2009)Heparan sulfate (HS) proteoglycans (PGs) interact with a number of extracellular signaling proteins, thereby playing an essential role in the regulation of many physiological processes. One major function of HS is to ... -
Decline in arylsulfatase B (N-acetylgalactosamine-4-sulfatase) leads to increased EGFR expression due to SHP2 inhibition and JNK activation in prostate
Bhattacharyya, S.; Feferman, L.; Han, X.; Ouya, Y.; Zhang, F.; Linhardt, Robert J.; Tobacman, J.K. (The American Society for Biochemistry and Molecular Biology (ASBMB) and Elsevier, 2018)Epidermal growth factor receptor (EGFR) has a crucial role in cell differentiation and proliferation and cancer, and its expression appears to be up-regulated when arylsulfatase B (ARSB or GalNAc-4-sulfatase) is reduced. ... -
Differential effect of homologous NicR2A/NicR2Bs and endogenous ectopic strong promoters on nicotine metabolism in Pseudomonas sp. JY-Q
Huang, C.; Shan, L.; Chen, Z.; He, Z.; Li, J.; Yang, Y.; Shu, M.; Pan, F.; Jiao, Y.; Zhang, F.; Linhardt, Robert J.; Zhong, W. (2021)Nicotine is a toxic environmental pollutant that widely exists in tobacco wastes. As a natural nicotine-degrading strain, Pseudomonas sp. strain JY-Q still has difficulties degrading high concentrations of nicotine. In ... -
Divergent effect of glycosaminoglycans on the in vitro aggregation of serum amyloid A
Aguilera, J.J.; Beaudet, J.; Zhang, F.; Linhardt, Robert J.; Colón, W. (2014-01-01)Serum amyloid A (SAA) is an apolipoprotein involved in poorly understood roles in inflammation. Upon trauma, hepatic expression of SAA rises 1000 times the basal levels. In the case of inflammatory diseases like rheumatoid ... -
Effect of high glucose on glycosaminoglycans in cultured retinal endothelial cells and rat retina
Kaur, G.; Song, Y.; Xia, K.; McCarthy, K.; Zhang, F.; Linhardt, Robert J.; Harris, N.R. (2022)Introduction The endothelial glycocalyx regulates vascular permeability, inflammation, and coagulation, and acts as a mechanosensor. The loss of glycocalyx can cause endothelial injury and contribute to several microvascular ... -
Enzymatic synthesis of chondroitin sulfate E to attenuate bacterial lipopolysaccharide-induced organ damage
Li, J.; Sparkenbaugh, E.; Su, G.; Zhang, F.; Xu, Y.; Xia, K.; He, P.; Baytas, S.; Pechauer, S.; Padmanabhan, A.; Linhardt, Robert J.; Pawlinski, R.; Liu, J. (American Chemical Society (ACS), 2020)Chondroitin sulfate E (CS-E) is a sulfated polysaccharide that contains repeating disaccharides of 4,6-disulfated N-acetylgalactosamine and glucuronic acid residues. Here, we report the enzymatic synthesis of three homogeneous ...