Browsing Linhardt Research Labs Papers by Author "da Silva, C.L."
Now showing items 1-3 of 3
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Extracellular matrix decorated polycaprolactone scaffolds for improved mesenchymal stem/stromal cell osteogenesis towards a patient-tailored bone tissue engineering approach
Silva, J.C.; Carvalho, M.S.; Udangawa, R.N.; Moura, C.S.; Cabral, J.M.S.; da Silva, C.L.; Ferreira, F.C.; Vashishth, D.; Linhardt, Robert J. (2020-07-01)The clinical demand for tissue-engineered bone is growing due to the increase of non-union fractures and delayed healing in an aging population. Herein, we present a method combining additive manufacturing (AM) techniques ... -
Extruded bioreactor perfusion culture supports the chondrogenic differentiation of human mesenchymal stem/stromal cells in 3D porous poly (ε-caprolactone) scaffolds
Silva, J.C.; Moura, C.S.; Borrecho, G.; Alves de Matos, A.P.; da Silva, C.L.; Cabral, J.M.S.; Bártolo, P.J.; Linhardt, Robert J.; Ferreira, F.C. (2019)Novel bioengineering strategies for the ex vivo fabrication of native-like tissue-engineered cartilage are crucial for the translation of these approaches to clinically manage highly prevalent and debilitating joint diseases. ... -
Glycosaminoglycan disaccharide compositional analysis of cell-derived extracellular matrices using liquid chromatography-tandem mass spectrometry
Silva, J.C.; Carvalho, M.S.; Xia, K.; Cabral, J.M.S.; da Silva, C.L.; Ferreira, F.C.; Vashishth, D.; Linhardt, Robert J. (2020-01-01)Cell-derived extracellular matrices have emerged as promising scaffolds for tissue engineering (TE) strategies due to their ability to create a biomimetic microenvironment providing biochemical and physical cues to cells, ...