Now showing items 1-3 of 3

    • A mutant cell library for systematic analysis of heparan sulfate 

      Qiu, Hong; Shi, Songshan; Yue, Jingwen; Xin, Meng; Nairn, Alison V.; Lin, Lei; Liu, Xinyue; Li, Guoyun; Archer-Hartmann, Stephanie A.; Dela Rosa, Mitche; Galizzi, Melina; Wang, Shunchun; Zhang, Fuming; Azadi, Parastoo; van Kuppevelt, Toin H.; Cardoso, Wellington V.; Kimata, Koji; Ai, Xingbin; Moremen, Kelley W.; Esko, Jeffrey D.; Linhardt, Robert J.; Wang, Lianchun (Nature, 2018-11-01)
      Heparan sulfate (HS) is a complex linear polysaccharide that modulates a wide range of biological functions. Elucidating the structure–function relationship of HS has been challenging. Here we report the generation of an ...
    • Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function 

      Patel, Vaishali N.; Pineda, Dallas L.; Berenstein, Elsa; Hauser, Belinda R.; Choi, Sophie; Prochazkova, Michaela; Zheng, Changyu; Goldsmith, Corinne M.; van Kuppevelt, Toin H.; Kulkarni, Ashok; Song, Yuefan; Linhardt, Robert J.; Chibly, Alejandro M.; Hoffman, Matthew P. (Elsevier, 2021-09-01)
      Heparan sulfate 3-O-sulfotransferases generate highly sulfated but rare 3-O-sulfated heparan sulfate (HS) epitopes on cell surfaces and in the extracellular matrix. Previous ex vivo experiments suggested functional redundancy ...
    • Nucleolin: Acharan Sulfate-Binding Protein on the Surface of Cancer Cells 

      Joo, Eun Ji; ten Dam, Gerdy B.; van Kuppevelt, Toin H.; Toida, Toshihiko; Linhardt, Robert J.; Kim, Yeong Shik (Oxford, 2005-01-01)
      Glycosaminoglycans (GAGs) are complex polysaccharides that participate in the regulation of physiological processes through the interactions with a wide variety of proteins. Acharan sulfate (AS), isolated from the giant ...