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dc.rights.licenseCC BY — Creative Commons Attribution
dc.contributor.authorSordini, L.
dc.contributor.authorSilva, J.C.
dc.contributor.authorGarrudo, F.F.F.
dc.contributor.authorRodrigues, C.A.V.
dc.contributor.authorMarques, A.C.
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorCabral, J.M.S.
dc.contributor.authorMorgado, J.
dc.contributor.authorCastelo Ferreira, F.
dc.date2021
dc.date.accessioned2022-06-21T13:28:42Z
dc.date.available2022-06-21T13:28:42Z
dc.date.issued2021-08-02
dc.identifier.citationPEDOT:PSS-coated polybenzimidazole electroconductive nanofibers for biomedical applications, L. Sordini, J. C. Silva, F. F. F. Garrudo, C. A. V. Rodrigues, A. C. Marques, R. J. Linhardt, J. M. S. Cabral, J. Morgado, F. Castelo Ferreira, Polymers, 13, 2786, 2021.
dc.identifier.issn20734360
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5034
dc.identifier.urihttps://doi.org/10.3390/polym13162786
dc.descriptionPolymers, 13, 2786
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractBioelectricity drives several processes in the human body. The development of new materials that can deliver electrical stimuli is gaining increasing attention in the field of tissue engineering. In this work, novel, highly electrically conductive nanofibers made of poly [2,2′-m-(phenylene)-5,5′-bibenzimidazole] (PBI) have been manufactured by electrospinning and then coated with cross-linked poly (3,4-ethylenedioxythiophene) doped with poly (styrene sulfonic acid) (PEDOT:PSS) by spin coating or dip coating. These scaffolds have been characterized by scanning electron microscopy (SEM) imaging and attenuated total reflectance Fourier-transform infrared (ATR-FTIR) spectroscopy. The electrical conductivity was measured by the four-probe method at values of 28.3 S·m−1 for spin coated fibers and 147 S·m−1 for dip coated samples, which correspond, respectively, to an increase of about 105 and 106 times in relation to the electrical conductivity of PBI fibers. Human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) cultured on the produced scaffolds for one week showed high viability, typical morphology and proliferative capacity, as demonstrated by calcein fluorescence staining, 4′,6-diamidino-2-phenylindole (DAPI)/Phalloidin staining and MTT [3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide] assay. Therefore, all fiber samples demonstrated biocompatibility. Overall, our findings highlight the great potential of PEDOT:PSS-coated PBI electrospun scaffolds for a wide variety of biomedical applications, including their use as reliable in vitro models to study pathologies and the development of strategies for the regeneration of electroactive tissues or in the design of new electrodes for in vivo electrical stimulation protocols.
dc.description.sponsorshipFundação para a Ciência e Tecnologia
dc.languageen_US
dc.language.isoENG
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofPolymers
dc.relation.urihttps://harc.rpi.edu/
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titlePEDOT:PSS-coated polybenzimidazole electroconductive nanofibers for biomedical applicationsen_US
dc.typeArticle
dcterms.accessRightsA full text version is available in DSpace@RPI
dcterms.accessRightsOpen Access
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.3390/polym13162786
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.volume13


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Except where otherwise noted, this item's license is described as CC BY — Creative Commons Attribution