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dc.rights.licenseCC BY — Creative Commons Attribution
dc.contributor.authorZhi, Zijian
dc.contributor.authorChen, Jianle
dc.contributor.authorLi, Shan
dc.contributor.authorWang, Wenjun
dc.contributor.authorHuang, Rui
dc.contributor.authorLiu, Donghong
dc.contributor.authorDIng, Tian
dc.contributor.authorLinhardt, Robert J. John
dc.contributor.authorChen, Shiguo
dc.contributor.authorYe, Xingqian
dc.identifier.citationFast preparation of RG-I enriched ultra-low molecular weight pectin by an ultrasound accelerated Fenton process, Z. Zhi, J. Chen, S. Li, W. Wang, R. Huang, D. Liu, Tian Ding, R. J. Linhardt, S. Chen, X. Ye, Scientific Reports, 7, 541, 2017.
dc.descriptionFast preparation of RG-I enriched ultra-low molecular weight pectin by an ultrasound accelerated Fenton process
dc.description.abstractPectin, a natural polysaccharide found in the cell wall of most higher plant such as citrus, has drawn much attention due to its potential beneficial role in facilitating the treatment of many diseases like cancer, hyper cholesterol and diabetes. However, the broad application of pectin faces great limitations as the large molecular size of pectin severely prevents its bioavailability in vivo. In this study, we report an effective and highly convenient approach to degrade natural pectin into lower molecular pectin. By combining ultrasound with Fenton system (US-Fenton), we show that ultrasound synergistically enhances the efficiency of Fenton reaction to degrade pectin into 5.5 kDa within only 35 minutes. Importantly, RG-I domain, the most effective portion of natural pectin, was well preserved and highly enriched. In addition, the antioxidant activities of US-Fenton-treated pectin was significantly elevated. The mechanism of this novel observation was further investigated through the multiple structural analyses including HPLC, IR and NMR. Taken together, we present a novel and convenient approach to generate ultra-low molecular weight pectin with high efficiency and higher bioactivity. We expect our approach will have broader applications in improving the bioavailability and bioactivity of other polysaccharide-based natural compounds.
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofScientific Reports
dc.rightsAttribution 3.0 United States*
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleFast preparation of RG-I enriched ultra-low molecular weight pectin by an ultrasound accelerated Fenton processen_US
dcterms.accessRightsA full text version is available in DSpace@RPI
dcterms.accessRightsOpen Access
dc.rights.holderCC BY : this license allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. Credit must be given to the authors and the original work must be properly cited.
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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