Chemoenzymatic design of heparan sulfate oligosaccharides
Chemoenzymatic design of heparan sulfate oligosaccharides
Author
Liu, R.; Xu, Y.; Chen, M.; Weïwer, M.; Bridges, A.; DeAngelis, P.L.; Zhang, Q.; Linhardt, Robert J.; Liu, J.
Other Contributors
Date Issued
2010-10-29Subject
Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineeringDegree
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CC BY : this license allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. Credit must be given to the authors and the original work must be properly cited.; Attribution 3.0 United StatesFull Citation
Chemoenzymatic design of heparan sulfate oligosaccharides, R. Liu, Y. Xu, M. Chen, M. Weïwer, A. Bridges, P.L. DeAngelis, Q. Zhang, R. J. Linhardt, J. Liu, Journal of Biological Chemistry, 285, 34240-34249, 2010.Metadata
Show full item recordAbstract
Heparan sulfate is a sulfated glycan that exhibits essential physiological functions. Interrogation of the specificity of heparan sulfate-mediated activities demands a library of structurally defined oligosaccharides. Chemical synthesis of large heparan sulfate oligosaccharides remains challenging. We report the synthesis of oligosaccharides with different sulfation patterns and sizes from a disaccharide building block using glycosyltransferases, heparan sulfate C5-epimerase, and sulfotransferases. This method offers a generic approach to prepare heparan sulfate oligosaccharides possessing predictable structures.;Description
Journal of Biological Chemistry, 285, 34240-34249; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.Department
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);Publisher
ElsevierRelationships
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Journal of Biological Chemistry; https://harc.rpi.edu/;Access
Open Access; A full text version is available in DSpace@RPI; A full text version is available in DSpace@RPI;Collections
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