Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Synthesis of Uridine 5’-Diphosphoiduronic Acid: A Potential Substrate for the Chemoenzymatic Synthesis of Heparin, M.Weïwer, T. Sherwood, Dixy E. Green, M. Chen, P. L. DeAngelis, J. Liu, R. J. Linhardt, Journal of Organic Chemistry, 73, 7631-7637, 2008.
An improved understanding of the biological activities of heparin requires structurally defined heparin oligosaccharides. The chemoenzymatic synthesis of heparin oligosaccharides relies on glycosyltransferases that use UDP-sugar nucleotides as donors. Uridine 5'-diphosphoiduronic acid (UDP-IdoA) and uridine 5'-diphosphohexenuronic acid (UDP-HexUA) have been synthesized as potential analogues of uridine 5'-diphosphoglucuronic acid (UDP-GlcA) for enzymatic incorporation into heparin oligosaccharides. Non-natural UDP-IdoA and UDP-HexUA were tested as substrates for various glucuronosyltransferases to better understand enzyme specificity.;
Journal of Organic Chemistry, 73, 7631-7637; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
American Chemical Society (ACS)
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Journal of Organic Chemistry; https://harc.rpi.edu/;