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    CS Lyases: Structure, Activity and Applications in Analysis and the Treatment of Diseases

    Author
    Linhardt, Robert J.; Avci, Fikri Y.; Toida, Toshihiko; Kim, Yeong Shik; Cygler, Miroslaw
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    CS LYASES STRUCTURE ACTIVITY AND APPLICATIONS IN ANALYSIS.pdf (1.693Mb)
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    Date Issued
    2006-12-01
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    CS Lyases: Structure, Activity and Applications in Analysis and the Treatment of Diseases, R.J. Linhardt, F.Y. Avci, T. Toida, Y.S. Kim, M. Cygler, Chondroitin Sulfate Structure, Role and Pharmacological Activity-Advances in Pharmacology, N. Volpi Ed., Elsevier, Chapter 9, 2006.
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    URI
    https://hdl.handle.net/20.500.13015/5148; https://doi.org/10.1016/S1054-3589(05)53009-6
    Abstract
    Glycosaminoglycans (GAGs) are a family of highly sulfated, complex mixture of linear polysaccharides that display a wide array of biological activities (Boneu, 1996; Jackson et al., 1991). GAGs can be classified into four basic types—hyaluronan, chondroitin/dermatan sulfates (CS/DS), heparin/heparan sulfate, and keratan sulfate (Capila and Linhardt, 2002; Esko and Selleck, 2002; Iozzo, 1998; Linhardt and Toida, 2004). Chondroitin/dermatan sulfates are the focus of this chapter. Chondroitin/dermatan sulfates are linear, polydisperse GAGs with a repeating core of disaccharide structure composed of a d-glucopyranosyl uronic (GlcAp) acid or L-idopyranosyl uronic (IdoAp) acid glycosidically linked to 2-deoxy, 2-acetamido-d-galactopyranose (GalpNAc) residue (Fig. 1). The major classes of the chondroitin family of GAGs are: chondroitin; chondroitin-4-sulfate (CS-A); dermatan sulfate (CS-B or DS), and chondroitin-6-sulfate (CS-C).;
    Description
    Chondroitin Sulfate Structure, Role and Pharmacological Activity-Advances in Pharmacology, N. Volpi Ed., Elsevier, Chapter 9; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    Elsevier
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Advances in Pharmacology; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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