CS Lyases: Structure, Activity and Applications in Analysis and the Treatment of Diseases

Authors
Linhardt, Robert J.
Avci, Fikri Y.
Toida, Toshihiko
Kim, Yeong Shik
Cygler, Miroslaw
ORCID
https://orcid.org/0000-0003-2219-5833
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Issue Date
2006-12-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Full Citation
CS Lyases: Structure, Activity and Applications in Analysis and the Treatment of Diseases, R.J. Linhardt, F.Y. Avci, T. Toida, Y.S. Kim, M. Cygler, Chondroitin Sulfate Structure, Role and Pharmacological Activity-Advances in Pharmacology, N. Volpi Ed., Elsevier, Chapter 9, 2006.
Abstract
Glycosaminoglycans (GAGs) are a family of highly sulfated, complex mixture of linear polysaccharides that display a wide array of biological activities (Boneu, 1996; Jackson et al., 1991). GAGs can be classified into four basic types—hyaluronan, chondroitin/dermatan sulfates (CS/DS), heparin/heparan sulfate, and keratan sulfate (Capila and Linhardt, 2002; Esko and Selleck, 2002; Iozzo, 1998; Linhardt and Toida, 2004). Chondroitin/dermatan sulfates are the focus of this chapter. Chondroitin/dermatan sulfates are linear, polydisperse GAGs with a repeating core of disaccharide structure composed of a d-glucopyranosyl uronic (GlcAp) acid or L-idopyranosyl uronic (IdoAp) acid glycosidically linked to 2-deoxy, 2-acetamido-d-galactopyranose (GalpNAc) residue (Fig. 1). The major classes of the chondroitin family of GAGs are: chondroitin; chondroitin-4-sulfate (CS-A); dermatan sulfate (CS-B or DS), and chondroitin-6-sulfate (CS-C).
Description
Chondroitin Sulfate Structure, Role and Pharmacological Activity-Advances in Pharmacology, N. Volpi Ed., Elsevier, Chapter 9
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Elsevier
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Advances in Pharmacology
https://harc.rpi.edu/
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A full text version is available in DSpace@RPI