| dc.contributor.author | Du, Yuguo | |
| dc.contributor.author | Chen, Qi | |
| dc.contributor.author | Linhardt, Robert J. | |
| dc.date | 2006 | |
| dc.date.accessioned | 2022-06-23T03:56:07Z | |
| dc.date.available | 2022-06-23T03:56:07Z | |
| dc.date.issued | 2006-10-27 | |
| dc.identifier.citation | The First Total Synthesis of Sporiolide A, Y. Du, Q. Chen, R. J. Linhardt, Journal of Organic Chemistry, 71, 8446-8451, 2006. | |
| dc.identifier.issn | 223263 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.13015/5168 | |
| dc.identifier.uri | https://doi.org/10.1021/jo0615504 | |
| dc.description | Journal of Organic Chemistry, 71, 8446-8451 | |
| dc.description | Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform. | |
| dc.description.abstract | The first total synthesis of the natural cytotoxic agent sporiolide A has been accomplished from D-glucal in 16 steps with 6.1% overall yield. Carbohydrates were applied as the chiral templates to manipulate the absolute configuration during the synthesis. Pyridinium chlorochromate (PCC)-promoted transformation of the cyclic enol-ether to lactone, followed by Yamaguchi esterification and intramolecular ring closure metathesis, greatly facilitates synthesis of the target compound. | |
| dc.description.sponsorship | National Institute of Allergy and Infectious Diseases | |
| dc.language | en_US | |
| dc.language.iso | ENG | |
| dc.publisher | American Chemical Society (ACS) | |
| dc.relation.ispartof | The Linhardt Research Labs Online Collection | |
| dc.relation.ispartof | Rensselaer Polytechnic Institute, Troy, NY | |
| dc.relation.ispartof | Journal of Organic Chemistry | |
| dc.relation.uri | https://harc.rpi.edu/ | |
| dc.subject | Biology | |
| dc.subject | Chemistry and chemical biology | |
| dc.subject | Chemical and biological engineering | |
| dc.subject | Biomedical engineering | |
| dc.title | The First Total Synthesis of Sporiolide A | |
| dc.type | Article | |
| dcterms.accessRights | A full text version is available in DSpace@RPI | |
| dcterms.isPartOf | Journal | |
| dcterms.isVersionOf | https://doi.org/10.1021/jo0615504 | |
| dc.rights.holder | In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/ | |
| dc.creator.identifier | https://orcid.org/0000-0003-2219-5833 | |
| dc.relation.department | The Linhardt Research Labs. | |
| dc.relation.department | The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS) | |
| rpi.description.pages | 8446-8451 | |
| rpi.description.volume | 71 | |
