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    Increase in the Growth Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells by an O-Hexanoyl Low Molecular Weight Heparin Derivative

    Author
    Garg, Hari G.; Hales, Charles A.; Yu, Lunyin; Butler, Melissa; Islam, Tasneem; Xie, Jin; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    INCREASE IN THE GROWTH INHIBITION OF BOVINE PULMONARY ARTERY.pdf (735.7Kb)
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    Date Issued
    2006-11-06
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Increase in the Growth Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells by an O-Hexanoyl Low Molecular Weight Heparin Derivative, H. G. Garg, N. Cindhuchao, C. A. Hales, M. Butler, T. Islam, R. J. Linhardt, Carbohydrate Research, 341, 2607–2612, 2006.
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    URI
    https://hdl.handle.net/20.500.13015/5171; https://doi.org/10.1016/j.carres.2006.07.014
    Abstract
    Proliferation of pulmonary artery smooth muscle cells (PASMCs) appears to play a significant role in chronic pulmonary hypertension. The proliferation of PASMCs is strongly inhibited by some commercial heparin preparations. Heparin fragments were prepared by periodate treatment, followed by sodium borohydride reduction, to enhance potency. The tributylammonium salt of this fragmented heparin was O-acylated with hexanoic anhydride. Gradient polyacrylamide gel electrophoresis showed that the major heparin fragment contained eight disaccharide units. NMR analysis showed that approximately one hexanoyl group per disaccharide residue was present. The O-hexanoyl heparin fragments were assayed for growth inhibitory effect on bovine PASMCs in culture. This derivative was found to be more effective in growth inhibition of bovine PASMCs in culture than the heparin from which it was derived. In the future, it is envisioned that this or similar derivatives may be an effective treatment for pulmonary hypertension.;
    Description
    Carbohydrate Research, 341, 2607–2612; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    Elsevier
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Carbohydrate Research; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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