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    Immunological Activity of Chondroitin Sulfate

    Author
    Toida, Toshihiko; Sakai, Shinobu; Akiyama, Hiroshi; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    IMMUNOLOGICAL ACTIVITY OF CHONDROITIN SULFATE.pdf (1.591Mb)
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    Date Issued
    2006-12-01
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Immunological Activity of Chondroitin Sulfate, T. Toida, S. Sakai, H. Akiyama, R. J. Linhardt, Chondroitin Sulfate Structure, Role and Pharmacological Activity-Advances in Pharmacology, N. Volpi Ed., Elsevier, Chapter 19, 2006.
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    URI
    https://hdl.handle.net/20.500.13015/5173; https://doi.org/10.1016/S1054-3589(05)53019-9
    Abstract
    The use of chondroitin sulfate (CS) for the symptomatic treatment of osteoarthritis (OA) has become very popular; however, it has also been the subject of controversy for several reasons. First, the nutraceutical industry is less regulated than the pharmaceutical industry and thus, the nutraceutical CS often suffers from poor quality control. Second, the bioavailability of orally administered CS is not generally accepted. Third, the mechanism of the effect of CS for treatment of OA remains unclear. There is abundant in vitro and in vivo evidence from animal and human clinical studies demonstrating the efficacy and safety of CS. This chapter focuses on the immunological activity of structurally regulated CSs. The mechanism of this immunological activity appears to be through CS binding to receptors related to cytokine production in lymphocytes such as splenocytes.;
    Description
    Chondroitin Sulfate Structure, Role and Pharmacological Activity-Advances in Pharmacology, N. Volpi Ed., Elsevier, Chapter 19; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    Elsevier
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Advances in Pharmacology; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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