Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Immunological Activity of Chondroitin Sulfate, T. Toida, S. Sakai, H. Akiyama, R. J. Linhardt, Chondroitin Sulfate Structure, Role and Pharmacological Activity-Advances in Pharmacology, N. Volpi Ed., Elsevier, Chapter 19, 2006.
The use of chondroitin sulfate (CS) for the symptomatic treatment of osteoarthritis (OA) has become very popular; however, it has also been the subject of controversy for several reasons. First, the nutraceutical industry is less regulated than the pharmaceutical industry and thus, the nutraceutical CS often suffers from poor quality control. Second, the bioavailability of orally administered CS is not generally accepted. Third, the mechanism of the effect of CS for treatment of OA remains unclear. There is abundant in vitro and in vivo evidence from animal and human clinical studies demonstrating the efficacy and safety of CS. This chapter focuses on the immunological activity of structurally regulated CSs. The mechanism of this immunological activity appears to be through CS binding to receptors related to cytokine production in lymphocytes such as splenocytes.;
Chondroitin Sulfate Structure, Role and Pharmacological Activity-Advances in Pharmacology, N. Volpi Ed., Elsevier, Chapter 19; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Advances in Pharmacology; https://harc.rpi.edu/;