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    Isolation and Characterization of Heparan Sulfate from Various Murine Tissues

    Author
    Warda, Mohamad; Toida, Toshihiko; Zhang, Fuming; Sun, Peilong; Munoz, Eva; Xie, Jin; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    ISOLATION AND CHARACTERIZATION OF HEPARAN SULFATE FROM VARIOUS.pdf (1.319Mb)
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    Date Issued
    2006-11-01
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Isolation and Characterization of Heparan Sulfate from Various Murine Tissues, M. Warda, T. Toida, F. Zhang, P. Sun, E. Munoz, R. J. Linhardt, Glycoconjugate Journal, 23, 553-561, 2006.
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    URI
    https://hdl.handle.net/20.500.13015/5177; https://doi.org/10.1007/s10719-006-7668-1
    Abstract
    Heparan sulfate (HS), is a proteoglycan (PG) found both in the extracellular matrix and on cell surface. It may represent one of the most biologically important glycoconjugates, playing an essential role in a variety of different events at molecular level. The publication of the mouse genome, and the intensive investigations aimed at understanding the proteome it encodes, has motivated us to initiate studies in mouse glycomics focused on HS. The current study is aimed at determining the quantitative and qualitative organ distribution of HS in mice. HS from brain, eyes, heart, lung, liver, kidney, spleen, intestine and skin was purified from 6-8 week old male and female mice. The recovered yield of HS from these organs is compared with the recovered whole body yield of HS. Structural characterization of the resulting HS relied on disaccharide analysis and (1)H-NMR spectroscopy. Different organs revealed a characteristic HS structure. These data begin to provide a structural understanding of the role of HS in cell-cell interactions, cell signaling and sub-cellular protein trafficking as well as a fundamental understanding of certain aspects of protein-carbohydrate interactions.;
    Description
    Glycoconjugate Journal, 23, 553-561; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    Springer
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Glycoconjugate Journal; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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