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    Is Human Placenta Proteoglycan Remodeling Involved in Pre-Eclampsia?

    Author
    Warda, M.; Zhang, F.; Radwan, M.; Zhang, Z.; Kim, N.; Kim, Y.N.; Linhardt, Robert J.; Han, J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    IS HUMAN PLACENTA PROTEOGLYCAN REMODELING INVOLVED IN PRE.pdf (455.4Kb)
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    Date Issued
    2008
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Is Human Placenta Proteoglycan Remodeling Involved in Pre-Eclampsia? M. Warda, F. Zhang, M. Radwan, Z. Zhang, N. Kim, Y.N. Kim, R. J. Linhardt, J. Han, Glycoconjugate Journal, 25, 441–450, 2008.
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    URI
    https://hdl.handle.net/20.500.13015/5189; https://doi.org/10.1007/s10719-007-9090-8
    Abstract
    Impaired placento-fetal communication is a coherent symptom of exaggerated pre-eclampsia. The impact of the cellular expression of different glycosaminoglycans (GAGs) in this event on the placenta in pre-eclampsia is still obscure. This is the first study aimed at discovering the relationship between structural alterations of different sulfated GAGs at the molecular level and the development of pre-eclampsia in inflicted placenta. Sulfated GAGs were isolated and purified from control and pre-eclampsia placentas. The amount and the molecular weight of GAG in each tissue sample were measured. The polydispersity of the recovered GAG samples were determined by polyacrylamide gel electrophoresis. The disaccharide composition of chondroitin sulfate, dermatan sulfate and heparan sulfate were deduced by chondroitinase and heparinase depolymerization followed by liquid chromatography-mass spectrometry. The in vivo sulfo-modulation of GAGs in pre-eclampsia and control placenta were examined using RT-PCR to determine the transcription levels of different sulfotransferases involved in GAG biosynthesis. Marked differences in GAG sulfation patterns and mRNA level of encoding selected GAG O-sulfotransferases were observed in pre-eclampsia. These data suggest a linkage between pre-eclampsia and the observed alterations in placental GAGs and could provide new insights about the modulating role of GAGs in the development and the severity of placental pre-eclampsia.;
    Description
    Glycoconjugate Journal, 25, 441–450; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    Springer
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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