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    Pharmacokinetics and Pharmacodynamics of Oral Heparin Solid Dosage Form in Healthy Human Subjects

    Author
    Mousa, Shaker A.; Fuming Zhang,; Aljada, Ahmad; Chaturvedi, Seema; Takieddin, Majde; Haifeng Zhang,; Lianli Chi,; Cristina Castelli, M.; Friedman, Kristen; Goldberg, Michael M.; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    PHARMACOKINETICS AND PHARMACODYNAMICS OF ORAL HEPARIN SOLID.pdf (2.072Mb)
    Other Contributors
    Date Issued
    2007-12-01
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Pharmacokinetics and Pharmacodynamics of Oral Heparin Solid Dosage Form in Healthy Human Subjects, S. A. Mousa, F. Zhang, A. Aljada, S. Chaturvedi, M. Takieddin, H. Zhang, L. Chi, E. Arbit, M. C. Castelli, M.M. Goldberg, R. J. Linhardt, Journal of Clinical Pharmacology, 47, 1508-1520, 2007.
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    URI
    https://hdl.handle.net/20.500.13015/5196; https://doi.org/10.1177/0091270007307242
    Abstract
    The present investigation determined the molecular structure and the pharmacokinetic and pharmacodynamic profiles of oral unfractionated heparin containing oral absorption enhancer sodium N-[8-(2-hydroxybenzoyl) amino]caprylate, salcaprozate sodium (SNAC) and assessed the safety and tolerability of the orally dosed heparin solid dosage form versus other routes. Sixteen healthy men were included in this single-dose, 3-way crossover, randomized, open-label study. Disaccharide compositional analysis was performed using capillary high-performance liquid chromatography with electrospray ionization mass spectrometry detection. The pharmacodynamics of heparin were obtained from analysis of plasma anti-factor Xa, anti-factor IIa, activated partial thromboplastin time, and total tissue factor pathway inhibitor data. The molecular weight properties and the disaccharide composition of orally administered unfractionated heparin/SNAC and parenterally administered unfractionated heparin are identical and consistent with the starting pharmaceutical standard heparin. Furthermore, the anti-factor Xa/anti-factor IIa ratio achieved is of approximately 1:1. This is the first true pharmacokinetic study to measure the chemical compositions of heparin administered by different routes.;
    Description
    Journal of Clinical Pharmacology, 47, 1508-1520; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    American College of Clinical Pharmacology (ACCP)
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Journal of Clinical Pharmacology; https://harc.rpi.edu/;
    Access
    A full text version is available in DSpace@RPI;
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