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    Molecular Weight Dependent Tissue Factor Pathway Inhibitor Release by Heparin and Heparin Oligosaccharides

    Author
    Ma, Qing; Tobu, Mahmut; Schultz, Christopher; Jeske, Walter; Hoppensteadt, Debra; Walenga, Jeanine; Cornelli, Umberto; Lee, John; Linhardt, Robert J.; Hanin, Israel; Fareed, Jawed
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    MOLECULAR WEIGHT DEPENDENT TISSUE FACTOR PATHWAY INHIBITOR.pdf (1.017Mb)
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    Date Issued
    2007-02-28
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Molecular Weight Dependent Tissue Factor Pathway Inhibitor Release by Heparin and Heparin Oligosaccharides, Q. Ma, M. Tobu, C. Schultz, W. Jeske, D. Hoppensteadt, J. Walenga, U. Cornelli, J. Lee, R. Linhardt, I. Hanin, J. Fareed, Thrombosis Research, 119, 653-661, 2007.
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    URI
    https://hdl.handle.net/20.500.13015/5208; https://doi.org/10.1016/j.thromres.2006.05.007
    Abstract
    Heparin and low molecular weight heparins exert their vascular effects by mobilizing tissue factor pathway inhibitor (TFPI) from the vascular endothelium into the blood circulation. We compared the influence of molecular weight on the TFPI release by heparin and its fractions in a non-human primate model. Primates were treated with unfractionated heparin, a low molecular weight heparin (gammaparin), or a heparin-derived oligosaccharide mixture (C3). Endothelial TFPI release was determined using both immunologic and functional assays. After intravenous administration, all agents significantly increased TFPI levels (p<0.05) in a dose dependent manner. The increase produced by unfractionated heparin and gammaparin was greater than that by C3 at an equal dosage (p<0.05). With subcutaneous injection, all agents produced less TFPI release. Repeated administration of heparin-derived oligosaccharides gradually increased TFPI release. A 1.89 fold increase in TFPI levels was observed 4 days after C3 treatment (2.5 mg/kg). Our findings indicated that TFPI release is dependent on the molecular weight of heparin and its derivatives. Heparin oligosaccharides exert their vascular effects through increased TFPI release after long-term repeated administration.;
    Description
    Thrombosis Research, 119, 653-661; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    Elsevier
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Thrombosis Research; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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