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    Electron Detachment Dissociation of Glycosaminoglycan Tetrasaccharides

    Author
    Wolff, J.J.; Chi, L.; Linhardt, Robert J.; Amster, I.J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    ELECTRON DETACHMENT DISSOCIATION OF.pdf (750.8Kb)
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    Date Issued
    2007
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Electron Detachment Dissociation of Glycosaminoglycan Tetrasaccharides, J. J. Wolff, L. Chi, R. J. Linhardt, I. J. Amster, Journal of the American Society of Mass Spectrometry, 18, 234-244, 2007.
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    URI
    https://hdl.handle.net/20.500.13015/5213; https://doi.org/10.1016/j.jasms.2006.09.020
    Abstract
    The first application of electron detachment dissociation (EDD) to carbohydrates is presented. The structural characterization of glycosaminoglycan (GAG) oligosaccharides by mass spectrometry is a longstanding problem because of the lability of these acidic, polysulfated carbohydrates. Doubly-charged negative ions of four GAG tetrasaccharides are examined by EDD, collisionally activated dissociation (CAD), and infrared multiphoton dissociation (IRMPD). EDD is found to produce information-rich mass spectra with both cross ring and glycosidic cleavage product ions. In contrast, most of the product ions produced by CAD and IRMPD result from glycosidic cleavage. EDD shows great potential as a tool for locating the sites of sulfation and other modifications in glycosaminoglycan oligosaccharides.;
    Description
    Journal of the American Society of Mass Spectrometry, 18, 234-244; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    American Chemical Society (ACS)
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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