Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Hyaluronan and Heparin Reduced Silver Nanoparticles Having Antimicrobial Properties, M. M. Kemp, A. Kumar, D. Clement, P. Ajayan, S. Mousa, R. J. Linhardt, Nanomedicine, 4, 421-429, 2009.
Aims: Silver nanoparticles exhibit unique antibacterial properties that make these ideal candidates for biological and medical applications. We utilized a clean method involving a single synthetic step to prepare silver nanoparticles that exhibit antimicrobial activity. Materials & methods: These nanoparticles were prepared by reducing silver nitrate with diaminopyridinylated heparin (DAPHP) and hyaluronan (HA) polysaccharides and tested for their efficacy in inhibiting microbial growth. Results & discussion: The resulting silver nanoparticles exhibit potent antimicrobial activity against Staphylococcus aureus and modest activity against Escherichia coli. Silver–HA showed greater antimicrobial activity than silver–DAPHP, while silver–glucose nanoparticles exhibited very weak antimicrobial activity. Neither HA nor DAPHP showed activity against S. aureus or E. coli. Conclusion: These results suggest that DAPHP and HA silver nanoparticles have potential in antimicrobial therapeutic applications.;
Nanomedicine, 4, 421-429; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
Farrar, Straus and Giroux
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Nanomedicine; https://harc.rpi.edu/;