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    Hyaluronan and Heparin Reduced Silver Nanoparticles Having Antimicrobial Properties

    Author
    Kemp, Melissa M.; Kumar, Ashavani; Clement, Dylan; Ajayan, Pulickel; Mousa, Shaker; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    HYALURONAN- AND HEPARIN-REDUCED SILVER NANOPARTICLES WITH.pdf (2.052Mb)
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    Date Issued
    2009-07-13
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Hyaluronan and Heparin Reduced Silver Nanoparticles Having Antimicrobial Properties, M. M. Kemp, A. Kumar, D. Clement, P. Ajayan, S. Mousa, R. J. Linhardt, Nanomedicine, 4, 421-429, 2009.
    Metadata
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    URI
    https://hdl.handle.net/20.500.13015/5216; https://doi.org/10.2217/nnm.09.24
    Abstract
    Aims: Silver nanoparticles exhibit unique antibacterial properties that make these ideal candidates for biological and medical applications. We utilized a clean method involving a single synthetic step to prepare silver nanoparticles that exhibit antimicrobial activity. Materials & methods: These nanoparticles were prepared by reducing silver nitrate with diaminopyridinylated heparin (DAPHP) and hyaluronan (HA) polysaccharides and tested for their efficacy in inhibiting microbial growth. Results & discussion: The resulting silver nanoparticles exhibit potent antimicrobial activity against Staphylococcus aureus and modest activity against Escherichia coli. Silver–HA showed greater antimicrobial activity than silver–DAPHP, while silver–glucose nanoparticles exhibited very weak antimicrobial activity. Neither HA nor DAPHP showed activity against S. aureus or E. coli. Conclusion: These results suggest that DAPHP and HA silver nanoparticles have potential in antimicrobial therapeutic applications.;
    Description
    Nanomedicine, 4, 421-429; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    Farrar, Straus and Giroux
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Nanomedicine; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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