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    Synthesis of Gold and Silver Nanoparticles Stabilized with Glycosaminoglycans having Distinctive Biological Activities

    Author
    Kemp, Melissa M.; Kumar, Ashavani; Mousa, Shaymaa; Park, Tae Joon; Ajayan, Pulickel; Kubotera, Natsuki; Mousa, Shaker A.; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    SYNTHESIS OF GOLD AND SILVER NANOPARTICLES STABILIZED WITH.pdf (2.759Mb)
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    Date Issued
    2009-03-09
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Synthesis of Gold and Silver Nanoparticles Stabilized with Glycosaminoglycans having Distinctive Biological Activities, M. M. Kemp, A. Kumar, S. Mousa, T.-J, Park, N. Kubotera, S. Mousa, P. Ajayan, R. J. Linhardt, Biomacromolecules, 10, 589–595, 2009.
    Metadata
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    URI
    https://hdl.handle.net/20.500.13015/5221; https://doi.org/10.1021/bm801266t
    Abstract
    Metal nanoparticles have been studied for their anticoagulant and anti-inflammatory efficacy in various models. Specifically, gold and silver nanoparticles exhibit properties that make these ideal candidates for biological applications. The typical synthesis of gold and silver nanoparticles incorporates contaminants that could pose further problems. Here we demonstrate a clean method of synthesizing gold and silver nanoparticles that exhibit biological functions. These nanoparticles were prepared by reducing AuCl4 and AgNO3 using heparin and hyaluronan, as both reducing and stabilizing agents. The particles show stability under physiological conditions, and narrow size distributions for heparin particles and wider distribution for hyaluronan particles. Studies show that the heparin nanoparticles exhibit anticoagulant properties. Additionally, either gold- or silver- heparin nanoparticles exhibit local anti-inflammatory properties without any significant effect on systemic hemostasis upon administration in carrageenan-induced paw edema models. In conclusion, gold and silver nanoparticles complexed with heparin demonstrated effective anticoagulant and anti-inflammatory efficacy, having potential in various local applications.;
    Description
    Biomacromolecules, 10, 589–595; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    American Chemical Society (ACS)
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Biomacromolecules; https://harc.rpi.edu/;
    Access
    A full text version is available in DSpace@RPI;
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