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    Lessons learned from the contamination of heparin

    Author
    Liu, Haiying; Zhang, Zhenqing; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    LESSONS LEARNED FROM THE CONTAMINATION OF HEPARIN.pdf (1.878Mb)
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    Date Issued
    2009-03-09
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Lessons learned from the contamination of heparin, H. Liu, Z. Zhang, R.J. Linhardt, Natural Product Reports, 26, 313–321, 2009.
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    URI
    https://hdl.handle.net/20.500.13015/5222; https://doi.org/10.1039/b819896a
    Abstract
    Heparin is unique as one of the oldest drugs currently still in widespread clinical use as an anticoagulant, a natural product, one of the first biopolymeric drugs, and one of the few carbohydrate drugs. Recently, certain batches of heparin have been associated with anaphylactoid-type reactions, some leading to hypotension and death. These reactions were traced to contamination with a semi-synthetic oversulfated chondroitin sulfate (OSCS). This Highlight reviews the heparin contamination crisis, its resolution, and the lessons learned. Pharmaceutical scientists now must consider dozens of natural and synthetic heparinoids as potential heparin contaminants. Effective assays, which can detect both known and unknown contaminants, are required to monitor the quality of heparin. Safer and better-regulated processes are needed for heparin production.;
    Description
    Natural Product Reports, 26, 313–321; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    Royal Society of Chemistry
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Natural Product Reports; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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