Show simple item record

dc.contributor.authorGarg, H.G.
dc.contributor.authorMrabat, H.
dc.contributor.authorYu, L.
dc.contributor.authorFreeman, C.
dc.contributor.authorLi, B.
dc.contributor.authorZhang, F.
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorHales, C.A.
dc.date2008
dc.date.accessioned2022-06-23T04:01:54Z
dc.date.available2022-06-23T04:01:54Z
dc.date.issued2008
dc.identifier.citationSignificance of 2-O-Sulfonate Group of L-Iduronic Acid Residues in Heparin on the Growth Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells, H. G.Garg, H. Mrabat, L. Yu, C. Freeman, B. Li, F. Zhang, R. J. Linhardt, C. A. Hales, Carbohydrate Research, 343, 2406-2410, 2008.
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5226
dc.identifier.urihttps://doi.org/10.1016%2Fj.carres.2008.06.022
dc.descriptionCarbohydrate Research, 343, 2406-2410
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractHeparin inhibits the growth of several cell types in vitro, including bovine pulmonary artery smooth muscle cells (BPASMCs). To understand more about the heparin structure required for endogenous activity, chemically modified derivatives of native heparin and glycol-split heparin namely, 2-O-desulfonated iduronic/glucuronic acid residues in heparin, and 2-O-desulfonated iduronic residues in glycol-split heparin were prepared. These were assayed for their antiproliferative potency on cultured BPASMCs. All of the 2-O-desulfonated heparin derivatives had significantly decreased less antiproliferative activity on BPASMCs. These results suggest that the 2-O-sulfo group of iduronic acid residues in heparin’s major sequence is essential for the antiproliferative properties of heparin. The size of heparin does not affect the growth inhibitory properties of heparin on BPASMCs at the three dose levels examined.
dc.languageen_US
dc.language.isoENG
dc.publisherElsevier
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleSignificance of 2-O-Sulfonate Group of L-Iduronic Acid Residues in Heparin on the Growth Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells
dc.typeArticle
dcterms.accessRightsA full text version is available in DSpace@RPI
dcterms.isVersionOfhttps://doi.org/10.1016%2Fj.carres.2008.06.022
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record