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    Oversulfated Chondroitin Sulfate: Impact of a Heparin Impurity, Associated with Adverse Clinical Events, on Low Molecular Weight Heparin Preparation

    Author
    Zhang, Z.; Weïwer, M.; Li, B.; Kemp, M.M.; Daman, T.H.; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    OVERSULFATED CHONDROITIN SULFATE IMPACT OF A HEPARIN IMPURITY.pdf (731.3Kb)
    Other Contributors
    Date Issued
    2008-09-25
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Oversulfated Chondroitin Sulfate: Impact of a Heparin Impurity, Associated with Adverse Clinical Events, on Low Molecular Weight Heparin Preparation, Z. Zhang, M. Weïwer, B. Li, M. M. Kemp, T. H. Daman, R. J. Linhardt Journal of Medicinal Chemistry, 51, 5498-5501, 2008.
    Metadata
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    URI
    https://hdl.handle.net/20.500.13015/5233; https://doi.org/10.1021/jm800785t
    Abstract
    Heparin, a widely used anticoagulant, is being rapidly displaced by low-molecular-weight heparins. Recently, certain lots of heparin have been associated with anaphylactoid-type reactions resulting from contamination with oversulfated chondroitin sulfate. This impurity has also contaminated low-molecular-weight heparins obtained by chemical and enzymatic depolymerization of heparin. The sensitivity of oversulfated chondroitin sulfate to five different depolymerization processes similar to ones used in preparing low-molecular-weight heparins is reported.;
    Description
    Journal of Medicinal Chemistry, 51, 5498-5501; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    American Chemical Society (ACS)
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Journal of Medicinal Chemistry; https://harc.rpi.edu/;
    Access
    A full text version is available in DSpace@RPI;
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