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    Glycosaminoglycan characterization by electrospray ionization mass spectrometry including Fourier transform mass spectrometry

    Author
    Laremore, Tatiana N.; Leach, Franklin E.; Solakyildirim, Kemal; Amster, I. Jonathan; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    GLYCOSAMINOGLYCAN CHARACTERIZATION BY ELECTROSPRAY IONIZATION.pdf (1.023Mb)
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    Date Issued
    2010-01-01
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Glycosaminoglycan characterization by electrospray ionization mass spectrometry including Fourier transform mass spectrometry, T. N. Laremore, F. E. Leach III, K. Solakyildirim, I. J. Amster, R. J. Linhardt, Methods in Enzymology, 478, 79-108, 2010.
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    URI
    https://hdl.handle.net/20.500.13015/5249; https://doi.org/10.1016/S0076-6879(10)78003-4
    Abstract
    Electrospray ionization mass spectrometry (ESI MS) is a versatile analytical technique in glycomics of glycosaminoglycans (GAGs). Combined with enzymology, ESI MS is used for assessing changes in disaccharide composition of GAGs biosynthesized under different environmental or physiological conditions. ESI coupled with high-resolution mass analyzers such as a Fourier transform mass spectrometer (FTMS) permits accurate mass measurement of large oligosaccharides and intact GAGs as well as structural characterization of GAG oligosaccharides using information-rich fragmentation methods such as electron detachment dissociation. The first part of this chapter describes methods for disaccharide compositional profiling using ESI MS and the second part is dedicated to FTMS and tandem MS methods of GAG compositional and structural analysis.;
    Description
    Methods in Enzymology, 478, 79-108; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    Elsevier
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Methods in Enzymology; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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